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Liu Baorui, et al, . Overexpression of Mutant P53 Protein is Associated with Gastric Carcinoma Metastasising to Oemote Rrgans[J]. Cancer Research on Prevention and Treatment, 1996, 23(4): 201-202.
Citation: Liu Baorui, et al, . Overexpression of Mutant P53 Protein is Associated with Gastric Carcinoma Metastasising to Oemote Rrgans[J]. Cancer Research on Prevention and Treatment, 1996, 23(4): 201-202.
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Overexpression of Mutant P53 Protein is Associated with Gastric Carcinoma Metastasising to Oemote Rrgans

  • Department of Oncology, Xijing Hospital,The Fourth Military Medical University, Xian, 710032

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  • We have studied the expression of P53 in 62 patients with gastric carcinomas. A standard immunohistochemical technique employing the anti P53 monoclonal antibody (Pab1801) was applied to the routinly fixed and paraffin-embedded material from these tumors. These data suggest that the overexpression of the P53 oncoprotein is an independent marker for poor prognosis in gastric patients.
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    • References (5)
  • 1 Matozaki T, et al. Ps3 gene mutations in human gastriccancer: wild type Ps3 but not mutant Pss suppresses growth of human gastric cancer cells. Cancer Res,1992, 52:4335.
    2 Levine AJ, et al. The Pss tumor suppnessor gene. Nature, 1991，351 .453.
    3 Kakeji Y, et al. Gastric cancer with Psa over-expressionhas high potential for metastasising to lymph nodes. Br. J Cancer, 1993, 67:589.
    4 Martin HM, et al. Pss expression and prognosis in gastric carcinoma. Int J Cancer, 1992, 50，859.
    5 Joypaul BV, et al. The prognostic significance of the accumulation of Pss tumor suppressor gene protein in gastric adenocarcinoma. Br J Cancer, 1994, 69，943.
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