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DING Xiao-bo, JIN Gang, WANG Yan-bo, ZHAO Ying, WANG Ying-qiu, LIU Yu-ting. Clinical Application of 99Tcm-HL91 Hypoxia Imaging in Radiotherapy of Patients with Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 209-212. DOI: 10.3971/j.issn.1000-8578.2010.02.023
Citation: DING Xiao-bo, JIN Gang, WANG Yan-bo, ZHAO Ying, WANG Ying-qiu, LIU Yu-ting. Clinical Application of 99Tcm-HL91 Hypoxia Imaging in Radiotherapy of Patients with Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 209-212. DOI: 10.3971/j.issn.1000-8578.2010.02.023

Clinical Application of 99Tcm-HL91 Hypoxia Imaging in Radiotherapy of Patients with Non-small Cell Lung Cancer

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  • Received Date: October 06, 2008
  • Revised Date: December 25, 2008
  • Objective To detect hypoxia status of non-small cell lung cancer with serial 99Tcm -4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (HL91) SPECT images and predict the short-time curative effect about radiotherapy in lung cancer. Methods Thirty-one patients with non-small cell lung cancer underwent SPECT imaging at 4h and 24h after injecting 99Tcm-HL91,respectively.Regions of interest(R0Is)were drawn in the tumor(T)and contralateral position(N)and the radioactivity ratios of tumor to normal(T/N)were calculated semiquantitatively.Then patients treated by three-dimensional conformal radiotherapy(3D-CRT)underwent 99Tcm-HL91 hypoxia imaging two days before and after radiotherapy,respectively.Patients were divided into low intake group and high intake group according to the T/N value( 24h) before radiotherapy,the changes of T/N value after radiotherapy was analyzed on the transaxial view. Results The short-time effective power of radiotherapy patients in low intake group were higher than that in high intake group(P<0.05).There was a significantly statistical difference between these groups(P<0.05). Conclusion Technetium-99m-labeled HL91 hypoxia imaging of lung cancer can be used to predict its short-time curative effect after radiotherapy.
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