Clinical Study of All-trans-retinoic Acid in Redifferentiation Therapy for Thyroid Cancer

Objective To evaluate the effectiveness of retinoid therapy for improving 131I uptake in metastasized thyroid cancer with lower or lost radioiodine uptake ability. Methods A total of 32 thyroid cancer patients with insufficient or no radioiodine uptake (24 differentiated thyroid cancer, 8 non-differentiated thyroid cancer) were treated with all-trans-retinoic acid (ATRA) 1.0 to 1.5 mg/kg/day for 6 weeks before further radioiodine therapy. Three parameters for assessment of ATRA effects were established: (a)...