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HU Wei-dong, YANG Guo-liang, YUAN Hong-yin. A Relative Study on Microvessel Density to Prognosis of Axillary-node Negative Breast Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 272-274.
Citation: HU Wei-dong, YANG Guo-liang, YUAN Hong-yin. A Relative Study on Microvessel Density to Prognosis of Axillary-node Negative Breast Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 272-274.
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A Relative Study on Microvessel Density to Prognosis of Axillary-node Negative Breast Cancer

  • Department of Oncology, the Second Affiliated Hospital of Hu Beii Medical University, Wu Han 430071

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  • Objective: To determine the relation of microvessel density (MVD)to the prognosis and the clinicopathological factors in axillary-node-negative breast cancer (ANNBC). Methods: MVD in 120 cases paraffin specimens of ANNBC. were examinated using imminohistochemistry technique. The relationship between MVD and overall survival (OS), relapsefree survival (RFS), metastasis-free survival (MFS) were analysed, respectively, as well as it was done between MVD and five clinicopathological factors. Results: The mean MVD was 38.21 ±18.72. It didn't relate to those clinicopathological factors. MVD in relapse and metastasis group which was apparently higher than that in desease-free group; OS, RFS, MFS curve in higher MVD group (MD >38) were significiantly lower those that in lower MVD group (MVD ≤38), respectively ; COX model indicated that MVD was an independent prognostic factor in ANNBC. Conclusion: MVD may be a good prognostic indicator for patients with ANNBC.
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  • [1]
    McGi re WL, Clark GM. Prognostic factors and treatments deci sion in axillary-node-negat ive breast cancer. N Engl J Med, 1992 , 326: 1756-61;
    [2]
    左文述, 徐忠法, 刘奇主编.现代乳腺肿瘤学.山东科学技术出版社, 1996, 99-111;
    [3]
    Folkman J.What is the evidence 　that tumors are angiogenesis dependent J Natl.Cancer Inst, 1990, 82: 4-6;
    [4]
    Bosai S, Lee AK, Delellis RA, etal. Microvessel quantitation and prognosis in invasive breast carcinoma. Human Pathol, 1992, 23: 755-761;
    [5]
    Weidner N, Semple JP, welch WR, et al. Tumor angiogenesis and metastasis correlation in invasive breast carcincma. N Engl J Med, 1991: 324: 1-8;
    [6]
    Dvorak HF, Brown LF, Detmar M, etal. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am J Pathol, 1995, 146: 1029-39;
    [7]
    Collins PD, Connly DT, Wil liams TJ. Characterization of the increase in vascular permeabi lity induced by vascular permeability factor in vivo.Br J phamacol, 1993, 109: 195-199;
    [8]
    Harris AL, zhang H , Moghaddam, etal. Breast cancer angiogenesisnew approaches to therapy via anti angiogenesis, hypoxic, activated drugs and vascular tageting. Breast Cancer Res Treat, 1996, 38: 97-108.
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