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CHEN Teng, ZHAO Rong-hua, SHI Jin-hua, CHEN Jin-guo, SUN Yan-ping. Clinical Significance Of Measuring The Serum Laminin And Collagen Type Ⅳ in Patients With Colorectal Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 284-285.
Citation: CHEN Teng, ZHAO Rong-hua, SHI Jin-hua, CHEN Jin-guo, SUN Yan-ping. Clinical Significance Of Measuring The Serum Laminin And Collagen Type Ⅳ in Patients With Colorectal Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 284-285.
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Clinical Significance Of Measuring The Serum Laminin And Collagen Type Ⅳ in Patients With Colorectal Cancer

  • Department of General Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003

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  • The contents of Laminin (LN) and Collagen type Ⅳ (Col Ⅳ) in serum were measured by radioimmunoassay in patients with colorectal cancer. It was showed that the content of LN and Col Ⅳ in cancer group was significantly higher than those in control group (P <0.01), the content of LN and Col Ⅳ in group with lymph node metastases was higher than those in group without lymph node metastases (P <0.05). The content of LN in Dukes C group was hight than that in Dukes B group (P <0.05). There was a tendency that the content of serum Col Ⅳ increased with the advance of the Dukes clasification and content of serum Col Ⅳ in DukesD group was higher than that in Dukes B group. This implies that the contents of the serum LN and Col Ⅳ is closely related to the tumor invasion and metastases, and the assay of the LN and Col Ⅳ in serum may be useful to the diagnosis of colorectal cancer.
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    • References (7)
  • [1]
    Hewitt RE , Powe DG, Morrell K, etal. Laminin and Collagen Ⅳ subunit dist ribution in normal and neoplastic tissues of colorectum and breast. Br J Cancer, 1997, 75(2): 221;
    [2]
    Orre M, Rogers PA.Reduced vascular basementmembrane immunost aining in mucinous tumors of the ovary. Int J Cancer, 1998, 79(2): 139;
    [3]
    Enam SA, RosenblumML, Edvardsen K, Role of extracellular matrix in tumor invasion: migration of glioma cells along fibronectin-positive mesenchymal cell processes. Neurosurgery, 1998, 42(3): 599;
    [4]
    Ambiru S, Miyazaki M, Nakagawa K, etal. Increased serum type Ⅳ collagen 7-S levels in patients with hepatic etastasis. Am J Gastroenterology, 1995, 90(5): 783;
    [5]
    Khan A, Krishna M, Baker SP, etal. Cathepsin B expression and its correlation with tumorassociated laminin and tumor progression in gastric cancer. Arch Pathol Lab Med, 1998, 122(2): 172;
    [6]
    Orita H, Korenaga D, Maehara Y et al.Laminin dist ribution patterns are closely related to liver metast asi s in gastriv cancer . Cancer, 1993, 71(4): 1201;
    [7]
    王端年, 朱延波, 薛建元, 等.胃癌浸润转移与整合蛋白、Ⅳ型胶原酶及细胞外机质的关系.中华病理学杂志, 1994, 23(5): 278.
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