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HUANG Ling-sha, LAO Ming, SHEN Jing, CHEN Yan-hua, ZHAO Hui-liu. The Value of Combined Detection of GPDA, CA7-24 and CA50 in Diagnosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2005, 32(09): 560-561. DOI: 10.3971/j.issn.1000-8578.3110
Citation: HUANG Ling-sha, LAO Ming, SHEN Jing, CHEN Yan-hua, ZHAO Hui-liu. The Value of Combined Detection of GPDA, CA7-24 and CA50 in Diagnosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2005, 32(09): 560-561. DOI: 10.3971/j.issn.1000-8578.3110
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The Value of Combined Detection of GPDA, CA7-24 and CA50 in Diagnosis of Gastric Cancer

  • 1. Affiliated Cancer Hospital of Guangxi Medical University, Nanning 530021, China; 2. Experimental Cent re of Guangxi Medical University

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  • Corresponding author:

    HUANG Ling-sha

  • Received Date: December 23, 2004
  • Revised Date: April 05, 2005
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    • Abstract
  • Objective 　To study the diagnostic value of Glycyl Proline Dipeptidyl Aminopeptidase ( GPDA), CA7-24 and CA50 in gastric cancer. Methods 　Serum levels of GPDA, CA7-24 and CA50 in 125 patients with gastric cancer, 77 patients with benign gastric tumor and 50 normal controls were measured by electro-chemiluminescence immuno-assay (ECLIA) and radioimmunoassay and automatic biochemical analyzer. Results 　Sensitivities of GPDA, CA7-24 and CA50 in gastric cancer group were 62. 4 %, 68. 0 % and 54. 4 %, respectively, and the specificities were 97. 6 %, 97. 6 % and 98. 4 %, respectively. The sensitivity of combined detection of three tumor markers increased to 89. 6 %, and the specificity was 93. 7 %. Conclusion 　GPDA, CA7-24 and CA50 can serve as the serum tumor marker in clinical diagnosis of gastric cancer. Combined detection of three kinds of serum tumor makers increases the detective positive rate.
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