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LI Jian, ZHAO XI-wu, SHU Guo-rong, ZHANG Lan-shi, LI Long. The Value Of Measurement Of 4 Tumor Markers For Diagnosis And Evaluation Of Disease Extent In Patiets With Lung Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 278-280.
Citation: LI Jian, ZHAO XI-wu, SHU Guo-rong, ZHANG Lan-shi, LI Long. The Value Of Measurement Of 4 Tumor Markers For Diagnosis And Evaluation Of Disease Extent In Patiets With Lung Cancer[J]. Cancer Research on Prevention and Treatment, 1999, 26(4): 278-280.
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The Value Of Measurement Of 4 Tumor Markers For Diagnosis And Evaluation Of Disease Extent In Patiets With Lung Cancer

  • The Affiliated Hospital of Zhenjian Medical College, Zhenjian 212001

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  • Objective: To evaluat the value of measurement of 4 tumor markers (CEA, CA50, CA19-9, CA125) for diagnosis and evaluation of disease extent in patients with lung cancer. Methods: These tumor markers in serum were measured in 62 patients with lung cancers, and change of the markers were observed in 58 patients with different stage and after or before treatment. Results: Combination of these tumor markers increased sensitivity and accuracy of measurement, the most offective combination seemed to be CEA puls CA50 and CA19-9. The serum levels of the markers in patients with advanced disease (stage Ⅲ and Ⅳ) were significantly higher than in those with stage Ⅰ and Ⅱ. After surgery and chemotherapy (curative effects :CRPR), the serum levels of the markers in pafients was decrease significantly. Conclusion: Measurement of CEA, CA50 and CA19-9 in serum provide useful informafion for diagnosis and evaluation of disease extent in patients with lung cancer.
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  • [1]
    Mitsuhashi　N, Takahashi T, Sakruaih, etal. Establishment and characterization of a new human lung poorly differentiated adenocarcinoma cell line, Gll-1 producing carcinoembryonic antigen (CEA)and CA19-9. Lung Cancer, 1995, 12: 13;
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    Sakamoto K , Haga Y, Yoskimuera R, etal. Comparative effectiveness of the tumor diagnotic, CA19-9 CA125 and Carcinoembryonic antigen in patients with disease of the digestive system. Gut, 1987, 28: 323;
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    Holmgrem J, Lindholm L, Persson B, etal. Detection by monoclonal antibody of carbohydrateantigen CA50 in serum of patients with carcinoma. Br Med J,1984, 288: 1479;
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    Ohshio G, Yamaki K, Imamura T, etal. Di stribution the carbohydrate antigens, Du-PA N-2 and CA19-9 in tumors of the lung. Tumori, 1995, 8: 67;
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    Kimuru Y, Fujii T, Hamanoto K, etal. Serum CA125 level is a good prognostic indicator in lung cancer. Br J Cancer, 1990, 62: 676.
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