The Value Of Measurement Of 4 Tumor Markers For Diagnosis And Evaluation Of Disease Extent In Patiets With Lung Cancer

Objective: To evaluat the value of measurement of 4 tumor markers (CEA, CA50, CA19-9, CA125) for diagnosis and evaluation of disease extent in patients with lung cancer. Methods: These tumor markers in serum were measured in 62 patients with lung cancers, and change of the markers were observed in 58 patients with different stage and after or before treatment. Results: Combination of these tumor markers increased sensitivity and accuracy of measurement, the most offective combination seemed to be CEA puls CA50 and CA19-9. The serum levels of the markers in patients with advanced disease (stage Ⅲ and Ⅳ) were significantly higher than in those with stage Ⅰ and Ⅱ. After surgery and chemotherapy (curative effects :CRPR), the serum levels of the markers in pafients was decrease significantly. Conclusion: Measurement of CEA, CA50 and CA19-9 in serum provide useful informafion for diagnosis and evaluation of disease extent in patients with lung cancer.