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Zhang Dengxue, . Diagnostic valve of serum CA50 measurement in patients with carcinoma of stomach[J]. Cancer Research on Prevention and Treatment, 1995, 22(4): 224-226.
Citation: Zhang Dengxue, . Diagnostic valve of serum CA50 measurement in patients with carcinoma of stomach[J]. Cancer Research on Prevention and Treatment, 1995, 22(4): 224-226.
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Diagnostic valve of serum CA50 measurement in patients with carcinoma of stomach

  • affiliated Hospital of Qing dao medical college

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  • Serum CA50 antigen in the nomal individuals and carcinoma of the stomach was assayed by radioimmunoassay,CA50,one type of carbohydrate antigen,consisting mainly of sialylated glycolipid(a ganglioside)and sialylated,Can be isolated from the primary or metaslatic tumors.The serum CA50 content was measured in 52 nomal individuals,62 patients with carcinoma of the stomach and 32 pstients with benign disease of the stomach.The normal value was 3.80±2.45ku/L.The test values in cancer patients were significantly higher than those in normals or benign disease patients.Taking the normal mean value plus two times of standard deviation as positive,the positive rate was 82.3% for Carcinomar of stomach.There was only two positive in 52 normals with a false positive rate of 3. 7%. Furthermore, 38 patients,Cured by effective treatment,gave near normal CA50 value,It is shown that this metsod can be used in carcinoma of stomach diagnosis,differential diagnosis and the monitor, prediction of prognosis.
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  • 1 Holcngreen EJ, et al. Detection by monoclonal antibodyof carbohydrate antigen CA50 in serum of patient withcarcinoma. Br Med J, 1984, 288，1479
    2 Paganuzzi M, et al. Clinical evaluation of CA-50 in seraof patients with different tumors. In; Holmgreen EJ.Tumor marker antigens. Lund, Sweden: student litera-ture, 1985. 134
    3 陈智周.糖类抗原CAo。放射免疫抑制试验在肿瘤诊断和监测中的初步应用.中华肿瘤杂志，1987, (6)，435
    4 Hammarstrom S. Chemistry and immunology of CEA,CA199 and CA-50. In;Holmgreen E).ed. Tumor mark-er antigens. Lund，Sweden: student literature. 1985.32:49
    5 张登学.恶性钟瘤患者血清搪链抗原50的变化及临床意义.中华内科杂志，1992. 31 (12)，766.
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