Clinicopathologic Features and Epidermal Growth Factor Receptor Mutations Associated with Epithelial-mesenchymal Transition in Non-small Cell Lung Cancer

Objective To explore clinicopathologic features and epidermal growth factor receptor mutations associated with epithelial-mesenchymal transition in non-small cell lung cancer. Methods The status of epithelial-mesenchymal transition of 62 patients with surgically resected non-small cell lung cancer specimens were tested by immunohistochemical staining.The rate of tumor epithelial phenotype was calculated with stratification factors of clinicopathologic features and EGFR genotype.Statistical significance was assessed by chi2square test s and logistic regression. Results 　The overall f requency rate of epithelial phenotype among 62 NSCLC was 35. 48 % (22 of 62) . The f requency of epithelial phenotype ( E2cadherinpositive) was greater for EGFR mutant s versus wild types (77. 78 % versus 18. 18 %; P < 0. 0001) ;females patient s versus males patient s (54. 55 % versus 25 %; P = 0. 02) ;adenocarcinomas versus other histology (39. 47 % versus 29. 17 %; P = 0. 4087 ) ; never smokers versus ever smokers ( 42. 42 % versus 27. 59 %; P = 0. 2231) ;age < 60 year versus age ≥60 year (43. 33 % versus 28. 12 %; P = 0. 211) ; earlystage disease versus advanced disease (38. 24 % versus 32. 12 %; P = 0. 6178) . Conclusion 　The clinicopathologic features of patient s with lung cancer showing epithelial markers tend to be women, nonsmokers, adenocarcinoma and with EGFR mutation.