Expression of Wnt1，β-catenin，PC and cyclinD1 Proteins in Gastric Carcinoma

ObjectiveTo detect the expression of Wnt1，β-catenin，APC and cyclin D1 proteins in human gastric carcinoma. Methods The immunohistochemical staining(LASB) was performed in 45 specimens and normal tissue adjacent to tumor border (>5cm). Results In 45 cases gastric carcinoma，the positive rates of Wnt1，β-catenin and cyclin D1 were 57.78％,73.33％ and 51.11％ respectively. In comparison，statistic difference is apparent because of their absence (excluding membrane expression of β-catenin) in normal tissue (P<0.01).However，APC expression is lower in gastric carcinoma than that in normal tissue (53.33% vs. 91.11％). There is marked significance likewise（P<0.01）.The co-expression (Wnt pathway is activated，Wnt+) rate of Wnt1，β-catenin and cyclin D1 is 44.44％，which is much higher than that in normal tissue（P<0.01）. Conclusion Wnt1-β-catenin-APC-cyclinD1 signal pathway is abnormal expressed in gastric carcinoma genesis.