Expression of p57 ^KIP2, cyclin D1, and cycl in Eand Their Clinical Significances in Squamous Cell Carcinoma of Uterine Cervix

Objective 　To discuss the effect s of p57 ^KIP2,cyclin D1, and cyclin E on the genesis and progression of carcinoma of the uterine cervix. Methods 　The expression of p57 ^KIP2, cyclin D1, and cyclin E proteins in 100 cases of squamous cell carcinoma of the uterine cervix, 60 cases of cervical int raepithelial neoplasia (CIN), and 30 cases of normal cervical squamous epithelium(NE) was detected respectively by immunohistochemical SP methods. Results 　The expression of cyclin D1, and cyclin E between SCC and NE, and between CIN and NE, and the expressionof cyclin E between CIN and NE had significant difference ( P < 0. 01) . In SCC, all the positive expression of p57 ^KIP2, cyclin D1 and cyclin E were no correlation with lymph node metastasis, and histological grade, and age ( P < 0. 01) . There was positive relationship between expression of cyclin D1 and cyclin E ( P < 0. 01) . Conclusion 　p57 ^KIP2, cyclin D1, and cyclin E might be useful in the development and progression of carcinoma of the uterine cervix. The over-expression of cyclin D1 and/or cyclin E proteins in SCC suggest that they might be important biological marker for malignant transformation in uterine cervix tissueand, and the abnormal expression of cyclin E were early event of carcinoma of the uterine cervix.