Express ion of nm23-H₁ Gene and ras Gene and Their Relations to Lymph Node Metastasis in Human Breast Cancer

Objective To explore the expression of nm23 gene and ras gene and the correlation with lymph node metastasis. Methods By using SP immunohistochemical methods,the nm23 H 1 and rasp21 expression of 76 breast tissues were detected,and the 5 year survival rate were followed up. Results nm23 H 1 gene expression were negative correlation with histologic tumor grade and lymph node metastasis ( P<0.005,P<0.05 ), and its expression was negative correlation with rasp21 expression in breast cancers,the pati...