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Pei Feng, Zhu Yi. Clinical Significance of Cytokeratin18 Fragments in Diagnosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(04): 439-441. DOI: 10.3971/j.issn.1000-8578.2012.04.018
Citation: Pei Feng, Zhu Yi. Clinical Significance of Cytokeratin18 Fragments in Diagnosis of Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(04): 439-441. DOI: 10.3971/j.issn.1000-8578.2012.04.018
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Clinical Significance of Cytokeratin18 Fragments in Diagnosis of Gastric Cancer

  • 1.Department of Gastrointestinal Surgery of Hubei Cancer Hospital，Wuhan 430079，China，2.Department of Clinical Laboratory (*：Tied for The First Author)

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  • Received Date: August 18, 2011
  • Revised Date: October 24, 2011
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    • Abstract
  • Objective To explore clinical significance of Cytokeratin18 Fragments in diagnosis of gastric cancer. Methods CLIA(chemiluminescence immunology analysis) was used to detect the serum level of CK18-3A9 in 236 cases of gastric cancer(186 cases of Gastric adenocarcinoma，50 cases of Signet-ring cell carcinoma)，150 cases of gastritis and gastric ulcer，and 165 healthy persons.ECLIA (electro-chemiluminescence analysis) was used to detect the serum levels of markers(CEA，CA199，CA72-4) in those people. Results The sensitivity and specificity of CK18-3A9 to diagnose gastric cancer were 36.02% and 97.5% respectively.The sensitivity and specificity of combined markers(CEA+CA199+CA72-4) were 33.47% and 97.5% respectively.The combined detection of CK18-3A9 and markers(CEA+CA199+CA72-4) to diagnose gastric cancer could increase the sensitivity up to 55.08% with significant difference (P<0.05)，also with the same specificity. Conclusion The detection of serum CK18-3A9 is helpful in the diagnosis of gastric cancer.Combination of serum CK18-3A9 with other markers(CEA+CA199+CA72-4) would improve the accuracy in diagnosis of gastric cancer.
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    • References (4)
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