Association of CYP1A1 and CYP1B1 Gene Polymorphisms with TypeⅠEndometrial Cancer in Chinese Women

Objective To investigate the relationship of cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1B1 (CYP1B1) gene polymorphism with the risk factors and susceptibility to typeⅠendometrial carcinoma in Chinese women.

Methods SNPshot technique was used to detect the polymorphism of CYP1B1, CYP1A1 and NQO1 genes in 103 patients with typeⅠendometrial carcinoma and 100 control subjects. Multivariate regression method analyzed the association of polymorphism with hypertension, susceptibility, obesity and other epidemiological risk factors.

Results The genetic frequencies of rs4646421 of CYP1A1 were statistically significantly different between two groups(P < 0.05). Compared with those carrying CT genotype, the individuals with CC genotype had less risk of endometrial cancer (OR=0.479, 95%CI: 0.255-0.899). The risk of endometrial carcinoma in the individuals with T allele was higher than those with C allele (OR=1.796, 95%CI: 1.203-2.680). Compared with CC genotype, TC+TT was associated with an increased risk of type Ⅰ endometrial cancer in women with hypertension, age > 60 years, BMI≥25 or menopausal delay (over 52 years old). There was no significant difference in the frequency of CYP1B1 gene SNPrs1056836 between the two groups(P > 0.05), but more basic cytosine mutations into guanine could increase the risk of typeⅠendometrial carcinoma (OR=0.604, 95%CI: 0.369-0.990).

Conclusion The rs4646421 polymorphism of SNP locus of CYP1A1 gene increases the risk of typeⅠendometrial carcinoma and is associated with epidemiological risk factors and expected to be a potential indicator of the screening of typeⅠendometrial cancer.