A Meta Analysis on Relationship between GSTP1 Ile105Val Genetic Polymorphisms and Lung Cancer Risk

ObjectiveTo study the relationship between glutathione-S-transferase P1 (GSTP1) Ile/Val genetic polymorphisms and lung cancer risk. MethodsDocuments were collected from databases. Study population were stratified by the ethnicity into Caucasians and the East-Asians ．The Meta-analysis was analyzed by RevMan software 4.2 to evaluate the risks (the odds ratio and 95% CI)for the overall or the subgroups. The sensitivity analysis and publication bias were evaluated. The forest plot and funnel plot of meta-analysis were indentified. ResultsA total of 6 601 cases and 6 821 controls from 15 studies were Caucasians and a total of 1 822 cases and 2 017 controls from 9 studies were East-Asians.The pooled OR for the overall or the subgroups of the 2 populations indicated no association. The sensitivity analysis indicated the outcome was stable. Publication bias existed in the studies for Caucasian,but in the East-Asians. ConclusionThis study indicates that the genetic polymorphism of GSTP1 Ile/Val was associated with the risks of lung cancer for neither Caucasians nor East-Asians, but subgroup analysis about smoking amount still required to be done.