Advanced Search
HUANG Zhao-hui, HUA Dong, LI Li-hua, MAO Yong, WU Xiao-hong. Prognostic Impact of GSTM1 and GSTP1 Polymorphism on Gastric Cancer Patients Treated with Platinum-based Adjuvant Chemotherapy[J]. Cancer Research on Prevention and Treatment, 2008, 35(06): 411-413. DOI: 10.3971/j.issn.1000-8578.2331
Citation: HUANG Zhao-hui, HUA Dong, LI Li-hua, MAO Yong, WU Xiao-hong. Prognostic Impact of GSTM1 and GSTP1 Polymorphism on Gastric Cancer Patients Treated with Platinum-based Adjuvant Chemotherapy[J]. Cancer Research on Prevention and Treatment, 2008, 35(06): 411-413. DOI: 10.3971/j.issn.1000-8578.2331
shu

Prognostic Impact of GSTM1 and GSTP1 Polymorphism on Gastric Cancer Patients Treated with Platinum-based Adjuvant Chemotherapy

  • Oncology Institute; The Fourth Affiliated Hospital of Suzhou University; Wuxi 214062; China

More Information
  • Received Date: July 15, 2007
  • Revised Date: September 05, 2007
    Graphical Abstract
    • Abstract
  • Objective 　To investigate the association of GSTM1 and GSTP1 polymorphisms with the clini2 cal outcome of gast ric cancer patient s t reated with platinum2based adjuvant chemotherapy. Methods 　A total of 84 patient s with gast ric cancer were recruited. All patient s received platinum2based adjuvant chemotherapy. PCR2LDR (ligation detection reaction) method was used to detect genotypes of GSTM12 null and GSTP1 Ile105Val. Results 　Of the 84 patient s, the prevalence of the GSTM12null genotype was 51. 2 % and the f requencies of GSTP1 Ile/ Ile, Ile/ Val and Val/ Val genotype were 61. 9 %, 28. 6 % and 9. 7 %, respectively. The recurrence2f ree survival rate and overall survival rate in patient s with GSTP1 Ile/ Val and Val/ Val genotype were significantly higher than those in patient s with Ile/ Ile genotype ( P <0. 05) . Multivariable analysis showed that GSTP1 Ile/ Ile genotype was associated with shorter recur2 rence2f ree survival ( P < 0. 05) . Conclusion 　Polymorphism of GSTP1 Ile105Val may be a potential prog2 nostic factor in gast ric cancer patient s t reated with platinum2based adjuvant chemotherapy.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]LV Minhao, QIN Li, LI Juntao, GUO Xuhui, LIU Fawen, CUI Shude, ZHANG Hengwei. 原发性乳腺癌分子分型与新辅助化疗疗效及预后的相关性[J]. Cancer Research on Prevention and Treatment, 2015, 42(08): 782-788. DOI: 10.3971/j.issn.1000-8578.2015.08.007
    [2]Wang Yuxiang, Wang Jun, Zhu Shuchai, Tian Dandan, Lv Dongjie, Wang Yi, Qiao Xueying. Comparison of Prognosis on Esopageal Carcinoma Treated with 3D-CRT and IMRT for Elderly Patients[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 1008-1013. DOI: 10.3971/j.issn.1000-8578.2012.08.031
    [3]Sun Jun, Zhang Qiang, Zhu Chen, Zhang Leilei, Ma Jiaming. Observation of Short-term Efficacy of Intensity-modulated Radiotherapy for Middle Thoracic Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(03): 318-320. DOI: 10.3971/j.issn.1000-8578.2012.03.018
    [4]WANG Yu-xiang, ZHU Shu-chai, QIU Rong, SU Jing-wei, SHEN Wen-bin. Prognosis of T4 Esophageal Carcinoma with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 690-694. DOI: 10.3971/j.issn.1000-8578.2011.06.023
    [5]WANG Jing, QIAO Xue-ying, JIA Jing-hao, LIU Xin, HUO Jun-jie, SONG Yu-zhi, GAO Xian-shu. Prognosis of Three Dimensional Conformal Radiotherapy of Locally Advanced Non-small Cell Lung Cancer with Involved-field[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 195-198. DOI: 10.3971/j.issn.1000-8578.2011.02.020
    [6]WANG Ren-sheng, WEI Bo, HUANG Su-ning, RUAN Chang-li. Clinical Observation of 128 Nasopharyngeal Carcinoma Patients for Intensity Modulated Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2010, 37(05): 570-574. DOI: 10.3971/j.issn.1000-8578.2010.05.022
    [7]WEI Rui, ZHANG Yang-de, HE Jian-tai, DAI You-yi. Postoperative Intensity Modulated Radiation Therapy for 30 Cases with Malignant Gliomas[J]. Cancer Research on Prevention and Treatment, 2010, 37(04): 453-456. DOI: 10.3971/j.issn.1000-8578.2010.04.023
    [8]ZHANG Hong-bo, CHEN Long-hua, WU De-hua, CAO Xiao-fei. Therapeutic Effects Evaluation of Three-dimensional Conformal Radiotherapy for Stage Ⅰ Primary Hepatocellular Carcinoma and Multi-factors Analysis of the Prognosis[J]. Cancer Research on Prevention and Treatment, 2007, 34(05): 378-381. DOI: 10.3971/j.issn.1000-8578.1674
    [9]HE Han-ping, GUO You-quan, HU Xin-chuan, XU Li-ming, WU Jian-ping. Three Dimension Radiotherapy of Lung Cancer with Brain Metastasis[J]. Cancer Research on Prevention and Treatment, 2006, 33(11): 831-833. DOI: 10.3971/j.issn.1000-8578.368
    [10]HE Xia, ZHAI Zhen-yu, JI Hong, ZHANG Yi-qin. The Short-term Clinical Observation of IMRT in First-treated Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2006, 33(04): 272-274. DOI: 10.3971/j.issn.1000-8578.3378

Catalog

    Get Citation
    PDF
    XML
    Article views (1860) PDF downloads (749) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Download Center

    Links

    Contact Us

    Address：116 Zhuodaoquan South Road,
    Hongshan District, Wuhan（430079）

    Tel：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    Email Alert RSS
    Total visits：11620806 Visits today：28566

    Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return