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YANG Guang-min, LI Shou-qing, MA Yin-fu, WEI Bing-bing, SHI Yang, TAN Yan. Anti-tumor Immunotherapy Effect of Co-expression Genetic Vaccine MAGE-1/IL-18[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 294-297. DOI: 10.3971/j.issn.1000-8578.2010.03.014
Citation: YANG Guang-min, LI Shou-qing, MA Yin-fu, WEI Bing-bing, SHI Yang, TAN Yan. Anti-tumor Immunotherapy Effect of Co-expression Genetic Vaccine MAGE-1/IL-18[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 294-297. DOI: 10.3971/j.issn.1000-8578.2010.03.014
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Anti-tumor Immunotherapy Effect of Co-expression Genetic Vaccine MAGE-1/IL-18

  • 1.Central Laboratory,The People's Hospital of Jilin Province,Changchun 130021,China;2.The First Hospital,Jilin University

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  • Received Date: June 08, 2009
  • Revised Date: December 16, 2009
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    • Abstract
  • Objective To observe specific immune response and anti-tumor immunotherapy effect of the co -expression genetic vaccine MAGE/IL-18. MethodsCo-expression genetic vaccine was injected to mice,two booster injections were carried out at ten days intervals.Using pcMAGE-1,pcIL-18,pcDNA3 and PBS as comparison,IL-12，IFN-γ，CTL killing activity and T cell subgroup were investigated.Tumor growth and survival rates of vaccine immunized MAGE(+) mice were recorded. Results The mice which were immunized by pcIL-18-MAGE,compared with control groups,had the highest CTL killing activity,CD3+,CD4+,CD8+ T cells,IL-12 and IFN-γ all step up obviously.The co-expression vaccine can delay tumor growth time and prolong the live time for mice. Conclusion Co-expression genetic vaccine pcIL-18-MAGE can induce conspicuous and has specific anti-tumor immunotherapy effect on laboratory animals,and can significantly reduce the tumor growth.
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