Advanced Search
SUN Wei, ZHOU Xiao-jun, MA Heng-hui, ZHANG Ru-song, LU Zhen-feng. Detection of Lymphatic Microvessel Density in Primary Gastric Adenocarcinoma and Its Clinicopathological Significance[J]. Cancer Research on Prevention and Treatment, 2008, 35(07): 512-514. DOI: 10.3971/j.issn.1000-8578.1861
Citation: SUN Wei, ZHOU Xiao-jun, MA Heng-hui, ZHANG Ru-song, LU Zhen-feng. Detection of Lymphatic Microvessel Density in Primary Gastric Adenocarcinoma and Its Clinicopathological Significance[J]. Cancer Research on Prevention and Treatment, 2008, 35(07): 512-514. DOI: 10.3971/j.issn.1000-8578.1861

Detection of Lymphatic Microvessel Density in Primary Gastric Adenocarcinoma and Its Clinicopathological Significance

More Information
  • Corresponding author:

    ZHOU Xiao2jun

  • Received Date: June 26, 2007
  • Revised Date: October 22, 2007
  • Objective  To investigate the clinicopathological significance of the lymphatic microvessel den2 sity (LMVD) in primary gast ric adenocarcinoma. Methods  Monoclonal antibody D2240 was used immu2 nohistochemically to detect the lymphatic microvessel density(LMVD) in the int ra2 and peri2tumoral areas of the primary gast ric adenocarcinoma and normal gast ric tissue, and analysis the relationship among the lymphatic microvessel density (LMVD), lymphatic invasion, lymph node metastasis and other clinico2 pathological parameters of the primary gast ric adenocarcinoma. Results  LMVD of the peri2tumoral area was significantly higher than that of int ra2tumoral area and nomal tissue ( P < 0. 05) . LMVD of the peri2 tumoral area was significantly associated with Ming Classification, lymphatic invasion and lymph node metastasis ( P < 0. 05), while less associated with age, sex, differentiation and invasion of the tumor ( P >0. 05) . LMVD of the int ra2tumoral area was not correlated with these clinicopathological parameters ( P >0. 05) . Conclusion  LMVD of the peri2tumoral area was significantly associated with lymphatic invasion and lymph node metastasis, and detection of LMVD in peri2tumoral area can be used for prediction of lymph node metastasis.
  • Related Articles

    [1]ZHUANG Jinman, LU Wanting, HUANG Yuxiu, HU Zhijian, LIN Zheng, HE Fei. Risk Factors of Lymph Node Metastasis in Early-stage Cervical Cancer Patients and Build of A Nomogram Prediction Model[J]. Cancer Research on Prevention and Treatment, 2019, 46(1): 50-54. DOI: 10.3971/j.issn.1000-8578.2019.18.0942
    [2]SUN Ronghao, LI Chao, FAN Jinchuan, WANG Shaoxin, WANG Wei, LIU Kun, LAN Xiaojiao, HE Yuxin. Relationship of Tumor Location and Other Clinicopathological Features with Differentiated Thyroid Cancer with Lymph Node Metastasis[J]. Cancer Research on Prevention and Treatment, 2014, 41(09): 993-997. DOI: 10.3971/j.issn.1000-8578.2014.09.009
    [3]YANG Runxiang, LIU Lin, MA Fei, Qian Haili, YANG Fang. Correlation between Expression of CCR7, D2-40 and Lymphatic Metastases in Thyroid Carcinoma[J]. Cancer Research on Prevention and Treatment, 2014, 41(05): 418-422. DOI: 10.3971/j.issn.1000-8578.2014.05.016
    [4]Zhu Yan, Yang Qichang, Liu Hongbin, Liu Manhua, Zhang Xiaojuan, Shen Yi. Expression of D2-40 and survivin in Cervical Carcinoma and Their Relation to Prognosis[J]. Cancer Research on Prevention and Treatment, 2012, 39(03): 307-311. DOI: 10.3971/j.issn.1000-8578.2012.03.016
    [5]YANG Run-xiang, REN Hong-xian, DUAN Lin-can, LUO Chun-xiang, LI Mei, LIU Lin. Relationship between D2-40 and CCR7 Expression and lymph Lymph Node Metastasis in Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(08): 921-925. DOI: 10.3971/j.issn.1000-8578.2011.08.017
    [6]SONG Ping-ping, ZHANG Wei-di, SUN Xue-mei, GUO Hong-bo, LIU Shu-guang, ZHANG Bai-jiang. Analysis of Metastasis of Thoracic Mediastinal Lymph Nodes in 63 Patients with Cardiac Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(07): 791-792. DOI: 10.3971/j.issn.1000-8578.2011.07.017
    [7]ZENG Jin-yan. A Meta Analysis of Relationship between COX-2 Expression and Lymph Node Metastasis in Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(05): 584-587. DOI: 10.3971/j.issn.1000-8578.2011.05.028
    [8]DON G Li, L I Weiping, YAN Wenjing, WU Suxiang. Relationship between Expression of VEGF2D and MLD and Lymph Node Metastasis in En2 dometrial Carcinoma[J]. Cancer Research on Prevention and Treatment, 2008, 35(12): 885-887. DOI: 10.3971/j.issn.1000-8578.1921
    [9]Yiskandaer, ZHANG Jian-qing, WANG Hai-feng, ZHANG Jin-rong, Aheli. Lymph Node Metastasis Rate and Metastasis Direction of Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2007, 34(02): 143-145. DOI: 10.3971/j.issn.1000-8578.3319
    [10]PEI Feng, FENG Mao-hui, YANG Guo-Liang, et al. The Relationship Between the Expression of nm23-H1 and Lymph Node Metastasis in Colorectal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2000, 27(05): 385-386. DOI: 10.3971/j.issn.1000-8578.192

Catalog

    Article views (2239) PDF downloads (724) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return