Advanced Search
WANG Fu-sheng, JING Mong-jie, ZHANG Tin-guo, et al, . Cyclin D1 Overexpression Cooperates with Activated Ras in the Progression of Gastric Carcinogenesis[J]. Cancer Research on Prevention and Treatment, 2000, 27(04): 260-261. DOI: 10.3971/j.issn.1000-8578.1305
Citation: WANG Fu-sheng, JING Mong-jie, ZHANG Tin-guo, et al, . Cyclin D1 Overexpression Cooperates with Activated Ras in the Progression of Gastric Carcinogenesis[J]. Cancer Research on Prevention and Treatment, 2000, 27(04): 260-261. DOI: 10.3971/j.issn.1000-8578.1305

Cyclin D1 Overexpression Cooperates with Activated Ras in the Progression of Gastric Carcinogenesis

More Information
  • Received Date: December 31, 1899
  • Revised Date: December 31, 1899
  • Objective To evaluate the relationship between the overexpression of cyclin D1 and Ras in the progression of gastric carcinogenesis. Methods The overexpression of cyclin D1 and Ras were studied in gastric carcinoma,precancerous lesions by immunohistochemical technique. Results The overexpression of cyclin D1 and Ras were observed in none of the 20 normal gastric mucosas.The positive rates of cyclin D1 and Ras were 59.2% and 57.1% in gastric cancer,respectively,and there was a significant correlation between the overexpressions of the two oncogenes (P<0.05).Cyclin D1 overexpression closely correlated to size of tumor (P<0.05) and adenocarcinoma (P<0.05),while Ras overexpression inversely correlated to poor differentiation (P<0.05),but closely correlated to intestinal carcinoma (P<0.05).The overexpression of cyclin D1 and Ras had no correlation with lymph node status (P>0.05),depth of invasion (P>0.05),and clinicopathologic stage (P>0.05). Conclusion The overexpression of cyclin D1 cooperated with activated ras in the process of malignant changes in the gastric mucosa and showed no prognostic significance.
  • Related Articles

    [1]LV Minhao, QIN Li, LI Juntao, GUO Xuhui, LIU Fawen, CUI Shude, ZHANG Hengwei. 原发性乳腺癌分子分型与新辅助化疗疗效及预后的相关性[J]. Cancer Research on Prevention and Treatment, 2015, 42(08): 782-788. DOI: 10.3971/j.issn.1000-8578.2015.08.007
    [2]Wang Yuxiang, Wang Jun, Zhu Shuchai, Tian Dandan, Lv Dongjie, Wang Yi, Qiao Xueying. Comparison of Prognosis on Esopageal Carcinoma Treated with 3D-CRT and IMRT for Elderly Patients[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 1008-1013. DOI: 10.3971/j.issn.1000-8578.2012.08.031
    [3]Sun Jun, Zhang Qiang, Zhu Chen, Zhang Leilei, Ma Jiaming. Observation of Short-term Efficacy of Intensity-modulated Radiotherapy for Middle Thoracic Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2012, 39(03): 318-320. DOI: 10.3971/j.issn.1000-8578.2012.03.018
    [4]WANG Yu-xiang, ZHU Shu-chai, QIU Rong, SU Jing-wei, SHEN Wen-bin. Prognosis of T4 Esophageal Carcinoma with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 690-694. DOI: 10.3971/j.issn.1000-8578.2011.06.023
    [5]WANG Jing, QIAO Xue-ying, JIA Jing-hao, LIU Xin, HUO Jun-jie, SONG Yu-zhi, GAO Xian-shu. Prognosis of Three Dimensional Conformal Radiotherapy of Locally Advanced Non-small Cell Lung Cancer with Involved-field[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 195-198. DOI: 10.3971/j.issn.1000-8578.2011.02.020
    [6]WANG Ren-sheng, WEI Bo, HUANG Su-ning, RUAN Chang-li. Clinical Observation of 128 Nasopharyngeal Carcinoma Patients for Intensity Modulated Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2010, 37(05): 570-574. DOI: 10.3971/j.issn.1000-8578.2010.05.022
    [7]WEI Rui, ZHANG Yang-de, HE Jian-tai, DAI You-yi. Postoperative Intensity Modulated Radiation Therapy for 30 Cases with Malignant Gliomas[J]. Cancer Research on Prevention and Treatment, 2010, 37(04): 453-456. DOI: 10.3971/j.issn.1000-8578.2010.04.023
    [8]ZHANG Hong-bo, CHEN Long-hua, WU De-hua, CAO Xiao-fei. Therapeutic Effects Evaluation of Three-dimensional Conformal Radiotherapy for Stage Ⅰ Primary Hepatocellular Carcinoma and Multi-factors Analysis of the Prognosis[J]. Cancer Research on Prevention and Treatment, 2007, 34(05): 378-381. DOI: 10.3971/j.issn.1000-8578.1674
    [9]HE Han-ping, GUO You-quan, HU Xin-chuan, XU Li-ming, WU Jian-ping. Three Dimension Radiotherapy of Lung Cancer with Brain Metastasis[J]. Cancer Research on Prevention and Treatment, 2006, 33(11): 831-833. DOI: 10.3971/j.issn.1000-8578.368
    [10]HE Xia, ZHAI Zhen-yu, JI Hong, ZHANG Yi-qin. The Short-term Clinical Observation of IMRT in First-treated Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2006, 33(04): 272-274. DOI: 10.3971/j.issn.1000-8578.3378

Catalog

    Article views (2292) PDF downloads (515) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return