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WANG Gui-lan, CHEN Li, E Qun, XIAO Yu-feng, ZHOU Li. Pathologic Significance of Expression of Integrin-β1 and VCAM-1 in Sinusoid-lemons of Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 958-961. DOI: 10.3971/j.issn.1000-8578.51
Citation: WANG Gui-lan, CHEN Li, E Qun, XIAO Yu-feng, ZHOU Li. Pathologic Significance of Expression of Integrin-β1 and VCAM-1 in Sinusoid-lemons of Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 958-961. DOI: 10.3971/j.issn.1000-8578.51

Pathologic Significance of Expression of Integrin-β1 and VCAM-1 in Sinusoid-lemons of Hepatocellular Carcinoma

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  • Corresponding author:

    CHEN Li

  • Received Date: November 13, 2006
  • Revised Date: March 18, 2007
  • Objective  To study the significance of the expressing of integrin-β1 (CD29), vascular cell adhesion molecule-1 (VCAM-1, CD106) in sinusoid2 lemons of the hepatocellular carcinoma ( HCC) . Methods  In 90 cases of HCC, the expression of VCAM-1 protein was detected by immunohistochemistry techniques SP, and that of integrin-β1 and PCNA proteins were detected by DouSP. The relativity of three facors were analysed with Multifactoral covariance method. Results  In HCC, integrin-β1 and VCAM-1 were expressed in sinusoid- lemons primarily, proliferating cell nuclear expressed PCNA. The expression of integrin-β1 was stronger in the pericarcinoma than in HCC. The positive rate of VCAM-1 expressed in HCC was as high as 76. 67 %, and was positively related to pathological grading. Multifactoral covariance analysis results shows the expression of integrin-β1 were all positively related to that of VCAM-1 in different grading groups, and they were significantly associated with PCNA of HCC in low-grading group, but the latter's relativity descreased in high-grading group. DouSP results : the co-expression of CD29 and PCNA was significantly much higher in HCC than in pericarcinoma tissues. Conclusion  Integrin-β1, VCAM-1 are stronger factors on the occurrence, development, proliferation and differerented of HCC. The expression of VCAM-1 is helpful to evaluating diagnosis and proliferation of HCC.
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