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WANG Yan-fen, DING Yong-ling, SHI Gong-sheng, WANG Dong-lin, ZHOU Xiao-ming, LI Jia-yu. Expression and Correlation of TGF-β1 and CD105 in Glioma Tissues[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 932-934. DOI: 10.3971/j.issn.1000-8578.60
Citation: WANG Yan-fen, DING Yong-ling, SHI Gong-sheng, WANG Dong-lin, ZHOU Xiao-ming, LI Jia-yu. Expression and Correlation of TGF-β1 and CD105 in Glioma Tissues[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 932-934. DOI: 10.3971/j.issn.1000-8578.60
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Expression and Correlation of TGF-β1 and CD105 in Glioma Tissues

  • 1. Department of Pathology, First Hospital of Yangzhou, Yangzhou 225001, China; 2. Department of Pathology, The Affiliated Hospital of Nantong University

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  • Corresponding author:

    WANG Yan-fen

  • Received Date: November 16, 2006
  • Revised Date: March 14, 2007
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    • Abstract
  • Objective 　To investigate the possible relationship between the expressions of TGF-β1 and CD105 in human gliomas and clinical significance. Methods 　The expressions of TGF-β1 and CD105 were examined by SP Immunohistochemical staining in 70 human glioma specimens and in 10 normal human brain tissue specimens, and their relationship s with clinic-pathological factors was also analyzed. Results The expressions of TGF-β1 and CD105 were closely associated with pathological grade ( P < 0. 01), but theirs expression in gliomas had no obvious relationship to the sexes, ages and sizes of tumor ( P > 0. 05) .The MVD values (37. 68 ±4. 91) in TGF-β1 positive groups was significantly higher than those (30. 01 ±5. 26) in negative groups ( P < 0. 01), and The expressions of TGF2β1 and CD105 were positively correlated ( r = 0. 6547, P < 0. 05) . Conclusion 　The cojioned overexpressions of TGF-β1 and CD105 may promote malignant proliferation and angiogenesis of glioma.
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