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Zhang Hongmei, Xu Lingling, An Guangyu. Evaluation of Bevadzumab Combined with FOLFIRI as First-line Treatment for Patients with Metastatic Colorectal Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 1001-1004. DOI: 10.3971/j.issn.1000-8578.2012.08.029
Citation: Zhang Hongmei, Xu Lingling, An Guangyu. Evaluation of Bevadzumab Combined with FOLFIRI as First-line Treatment for Patients with Metastatic Colorectal Cancer[J]. Cancer Research on Prevention and Treatment, 2012, 39(08): 1001-1004. DOI: 10.3971/j.issn.1000-8578.2012.08.029

Evaluation of Bevadzumab Combined with FOLFIRI as First-line Treatment for Patients with Metastatic Colorectal Cancer

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  • Received Date: March 01, 2012
  • Revised Date: May 14, 2012
  • Objective To assess the efficacy and safety of bevacizumab plus FOLFIRI for the first line treatment in metastatic colorectal cancer (mCRC) patients. Methods From May 2008 to July 2009,40 previously untreated mCRC patients received treatment of FOLFIRI (n=20) or FOLFIRI plus Bevacizumab(n=20).The treatment continued until disease progression or unacceptable toxicity.The data were retrospectively analyzed. Results All patients were evaluable for response,survival and toxicity analysis.The objective response rate of FOLFIRI and FOLFIRI plus Bevacizumab regimen groups was 25% (5/20) and 60% (12/20),respectively (χ2=5.013,P=0.025).The median disease-free survival (DFS) of FOLFIRI and FOLFIRI plus bevacizumab group was 5.1 and 10.1 months,respectively (χ2=9.703,P=0.002).The one-year survival rate was 48% and 70%,and the median overall survival (OS) was 11.0 and 18.0 months,respectively,with significant difference among the two treatment groups (χ2=5.852,P=0.016).The common toxicity profiles of FOLFIRI and FOLFIRI plus bevacizumab regimens were diarrhea and neutropenia,while the toxicity related to bevacizumab was consistent with that documented in previous literature such as hypertension,hemorrhage,cardiac,and proteinuria toxicity. Conclusion The addition of bevacizumab to FOLFIRI regimen significantly improves the response rate.DFS and OS in first-line treatment for patients with mCRC and its toxicity is well tolerated.
  • [1]
    Lee JC,Chow NH,Wang ST,et al.Prognostic value of vascular endothelial growth factor expression incolorectal cancer patients[J].Eur J Cancer,2000,36(6):748-53.
    [2]
    Dong ZW,Qiao YL,Li LD,et al.A report of cancer high incidence scene in china[J].Zhongguo ZhongLiu,2009,18(1):4-9.[董志伟,乔友林,李连弟,等.中国癌症高发现场报告[J].中国肿瘤,2009,18(1):4-9.]
    [3]
    Douillard JY,Cunningham D,Roth AD,et al.Irinotecan combined with fluorouracil compared withfluorouracil alone as first-line treatment for metastatic colorectal cancer:a multicentre randomisedtrial[J].Lancet,2000,355(9209):1041-7.
    [4]
    Kabbinavar F,Irl C,Zurlo A,et al.Bevacizumab improves the overall and progression-free survivalof patients with metastatic colorectal cancer treated with 5-fluorouracil-based regimens irrespectiveof baseline risk[J].Oncology,2008,75(3-4):215-23.
    [5]
    Kabbinavar FF,Hurwitz HI,Yi J,et al.Addition of bevacizumab to fluorouracil-based first-linetreatment of metastatic colorectal cancer:pooled analysis of cohorts of older patients from tworandomized clinical trials[J].J Clin Oncol,2009,27(2):199-205.
    [6]
    Chowdhury MW,Scaramuzzi RJ,Wheeler-Jones CP,et al.The expression of angiogenic growth factors andtheir receptors in ovarian follicles throughout the estrous cycle in the ewe[J].Theriogenology,2010,73(7):856-72.
    [7]
    Hurwitz H.Integrating the anti-VEGF-A humanized monoclonal antibody bevacizumab with chemotherapyin advanced colorectal cancer[J].Clin Colorectal Cancer,2004,4(Suppl 2):S62-8.
    [8]
    Tyagi P,Grothey A.Commentary on a phase III trial of bevacizumab plus XELOX or FOLFOX4 for first-line treatment of metastatic colorectal cancer:the NO16966 trial[J].Clin Colorectal Cancer,2006,6(4):261-4.
    [9]
    Okines A,Puerto OD,Cunningham D,et al.Surgery with curative-intent in patients treated withfirst-line chemotherapy plus bevacizumab for metastatic colorectal cancer First BEAT and therandomised phase-III NO16966 trial[J].Br J Cancer,2009,101(7):1033-8.
    [10]
    Sobrero A,Ackland S,Clarke S,et al.Phase IV study of bevacizumab in combination with infusionalfluorouracil,leucovorin and irinotecan (FOLFIRI) in first-line metastatic colorectal cancer[J].Oncology,2009,77(2):113-9.
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