Expression of p73, PTEN and Ki-67 Proteins in Endometrioid Adenocarcinoma and Their Significance

Objective To investigate significance and alterations in expression of p73, PTEN and Ki-67 proteins in endometrial carcinogenesis. Methods Immunohistochemistry was applied to detect expression of p73, PTEN and Ki-67 proteins in 13 normal proliferating endometria,20 simple hyperplasia,22 complex hyperplasia including 11 cases with atypical hyperplasia and 38 endometrioid adenocarcinomas. Results As malignant progression of lesions, the positive rates of p73 and ki-67 obviously increased, but that of PTEN dec...