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GUO Yan-li, JIN Guo-liang, GUO Wei, KUANG Gang, YANG Zhi-bin, DONG Zhi-ming. Relationship between Promoter Methylation of Wif-1 and Protein Expression of VEGF-C/VEGF-D in Gastric Cardia Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(09): 1044-1047. DOI: 10.3971/j.issn.1000-8578.2010.09.018
Citation: GUO Yan-li, JIN Guo-liang, GUO Wei, KUANG Gang, YANG Zhi-bin, DONG Zhi-ming. Relationship between Promoter Methylation of Wif-1 and Protein Expression of VEGF-C/VEGF-D in Gastric Cardia Adenocarcinoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(09): 1044-1047. DOI: 10.3971/j.issn.1000-8578.2010.09.018

Relationship between Promoter Methylation of Wif-1 and Protein Expression of VEGF-C/VEGF-D in Gastric Cardia Adenocarcinoma

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  • Received Date: May 11, 2009
  • Revised Date: November 03, 2009
  • Objective To investigate the promoter methylation of Wif-1 and the protein expression of VEGF-C and VEGF-D in gastric cardia adenocarcinoma (GCA) and normal mucosa. Methods A nested MSP method was applied to examine the CpG methylation of the Wif-1 in tumors and corresponding normal mucosa. Immunohistochemistry was used to determine the protein expression of VEGF-C and VEGF-D. Results The frequency of Wif-1 gene promoter methylation in GCA and corresponding normal mucosa were 61.7% and 34.0%, respectively. The frequency of Wif--1 gene promoter methylation in GCA was higher than that in normal mucosa (P=0.000). The positive rate of VEGF-C, VEGF-D were 63.8% and 76.6% in the GCA tissues, which were significantly higher than those in normal mucosa (P=0.000). The protein expression of VEGF-C and VEGF-D in methylated GCA tissues were higher than those in unmethylated tissues (PVEGF-C=0.008;PVEGF-D=0.022). Furthermore, the methylation frequency of Wif-1 gene was correlated with invasion depth and lymphatic metastasis (P<0.05), but not with pathology classification. Conclusion Promoter methylation of Wif-1 and the higher expression of VEGF-C, VEGF-D may contribute to pathogenesis of GCA.
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