Study on the Relationship between Hepatitis Virus(HBV) and Liver Damage in Chemotherapy of Lymphoma

Objective： Observing the ralationship between HBV and liver damage in chemotherapy of Lymphoma. Methods： Among 182 cases of lymphoma, 53 cases with positive serum HBV markerwhile 129 cases without HBV marker. The liver funtion of all cases were normal before chemotherapy, effort was made to observe the patients liver function damage after chemotherapy. Results： After two phasesregular chemotherapy, the liver damage was 45.3 % (24/53) in HBV(+) group and 27.1 % (35/129) in HBV(-)group (P <0.05). Furthermore, among the patients in HBV(+)group, 10 cases were treated with Interferon alfa -2b and the others didnt use the drug . Liver function damage was 10.0 %(1/10) in the former while 53.5 %(24/43) in the latter (P <0.05). Conclusion： The cases with HBV(+) were more likely to appear liver function damage, which could be alleviated by using Interferon alfa -2b.