Study about the Radiosensitivity and Heterogeneity of Human Gastric Cancer Cell Line (SGC-7901)

Objective: To study the radiosensitivity of human gastric cancer cell line(SGC-7901)and two subcell lines picked from the line. Methods: The cells of the cell line and two subcell lines (large clone and small clone) were radioted at different doses with 8MeV linear accelerator. Then the cells were incubated for 48h, 72h and clone culture. The survival curve was established by counting cell. Results: (1)The values of Do between two subcell lines were significantly different(P <0.05); (2)the values of Do between large clone subcell line and SGC-7901 cell line were significantly different (P <0.05). Conclusion: Heterogeneity of the radiosensitivity among SGC-7901 and the subcell lines is suggested.