Diagnostic Value of Peripheral Blood NLR and PLR in Gastrointestinal Pancreatic Neuroendocrine Neoplasm

Objective To explore the diagnostic value of peripheral blood NLR and PLR in gastrointestinal pancreatic neuroendocrine neoplasm.

Methods Blood cell analyzer was used to detect peripheral blood cell parameters of 95 cases pathologically diagnosed as GEP-NENs. NLR and PLR were calculated respectively, and 97 cases of chronic gastritis and 106 cases of healthy physical examination were taken as the control. ROC curve was used to analyze the diagnostic value of NLR/PLR for GEP-NENs and seek the cut-off value. We analyzed the relationship between NLR/PLR and clinicopathological features.

Results (1) The values of NLR (2.51±1.32) and PLR (148.26±72.99) in GEP-NENs group were significantly higher than those in chronic gastritis group and control group(P < 0.01). (2) Area under the ROC curve for NLR and PLR were 0.674 and 0.671, the cut-off value were 2.24 and 156.85, the sensitivity were 48% and 41%, and the specificity were 86% and 89%, respectively. (3) There was no apparent correlation between NLR/PLR and pathological grade(P > 0.05). According to the cut-off value, the GEP-NENs patients were divided into high value group and low value group, the chi-square test results showed no correlation between NLR/PLR values and clinicopathological parameters of GEP-NENs patients (P > 0.05).

Conclusion Peripheral blood NLR and PLR values are significantly increased in GEP-NENs patients, however, the diagnostic accuracy and positive rate of GEP-NENs are relatively low, without significant correlation with the severity or progression of disease.