Prognostive Value of Preoperative Fibrinogen Combined with Platelet-lymphocyte Ratio on Prognosis of Patients Undergoing Radical Cystectomy

YAO Zhiqiang; ZHANG Xiangxiang; CHEN Chaohu; CAO Jinlong; HAN Dali; LI Pan; DONG Zhichun; TIAN Junqiang

doi:10.3971/j.issn.1000-8578.2020.19.1631

Cancer Research on Prevention and Treatment > 2020 > 47(11): 834-838. > DOI: 10.3971/j.issn.1000-8578.2020.19.1631

YAO Zhiqiang, ZHANG Xiangxiang, CHEN Chaohu, CAO Jinlong, HAN Dali, LI Pan, DONG Zhichun, TIAN Junqiang. Prognostive Value of Preoperative Fibrinogen Combined with Platelet-lymphocyte Ratio on Prognosis of Patients Undergoing Radical Cystectomy[J]. Cancer Research on Prevention and Treatment, 2020, 47(11): 834-838. DOI: 10.3971/j.issn.1000-8578.2020.19.1631

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Prognostive Value of Preoperative Fibrinogen Combined with Platelet-lymphocyte Ratio on Prognosis of Patients Undergoing Radical Cystectomy

Department of Urology, Lanzhou University Second Hospital, Urology Institute of Lanzhou University Second Hospital, Key Laboratory of Gansu Province for Urological Diseases, Lanzhou 730030, China

Funding:

Health Industry Planning Project of Gansu Provincial Health GSWSKY2017-10

Lanzhou city, Gansu province Talent Innovation and Entrepreneurship Project 2019-RC-37

Science and Technology project of Chengguan District, Lanzhou city, Gansu province Science and Technology Bureau 2017KJGG0052

Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital CY2017-BJ16

Cuiying Graduate Supervisor Applicant Training Program of Lanzhou University Second Hospital 201704

More Information

Corresponding author:
TIAN Junqiang, E-mail: ery_tianjq@lzu.edu.cn
Received Date: March 20, 2020
Revised Date: August 16, 2020
Available Online: January 12, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the prognostive value of preoperative fibrinogen (FIB) combined with platelet-lymphocyte ratio (PLR) on the prognosis of patients undergoing radical cystectomy(RC).
Methods
We enrolled 141 patients with urothelial carcinoma after radical cystectomy. ROC curve was used to determine the optimal cutoff values of FIB and PLR. The FIB and PLR were divided into the high-level group and the low-level group. If one indicator was high-level or both indicators were high-level, a combination score 1 (S1) was defined. If both indicators were low-level, a combination score 0 (S0) was defined. One-way analysis of variance and non-parametric tests were used to analyze the characteristics of patients, the Kaplan-Meier method was used for univariate survival analysis, the Log rank method was used for testing, and the Cox proportional hazards model was used for multivariate regression analysis.
Results
The optimal cutoff values for FIB and PLR were 3.43 and 110.54, respectively. FIB level was closely related to T stage, pathological grade and tumor size (all P < 0.05), and PLR level was closely related to pathological grade and tumor size (P < 0.05). The preoperative combination score was closely related to T stage, N stage, pathological grade and tumor size (all P < 0.05). Combination score, T stage, tumor size, FIB and PLR were important factors affecting the prognosis. Combination score (P=0.019), T stage (P=0.021) and FIB (P=0.010) were independent risk factors for the prognosis.
Conclusion
The combination score is an independent risk factor for overall survival of patients undergoing radical cystectomy. It can be used as a new indicator for predicting the tumor progression and prognosis of patients with bladder cancer.
- Bladder cancer,
- Radical cystectomy,
- Fibrinogen,
- PLR,
- Prognosis

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References (24)

References

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Prognostive Value of Preoperative Fibrinogen Combined with Platelet-lymphocyte Ratio on Prognosis of Patients Undergoing Radical Cystectomy