| Citation: |
YAO Zhiqiang, ZHANG Xiangxiang, CHEN Chaohu, CAO Jinlong, HAN Dali, LI Pan, DONG Zhichun, TIAN Junqiang. Prognostive Value of Preoperative Fibrinogen Combined with Platelet-lymphocyte Ratio on Prognosis of Patients Undergoing Radical Cystectomy[J]. Cancer Research on Prevention and Treatment, 2020, 47(11): 834-838. DOI: 10.3971/j.issn.1000-8578.2020.19.1631
|
To investigate the prognostive value of preoperative fibrinogen (FIB) combined with platelet-lymphocyte ratio (PLR) on the prognosis of patients undergoing radical cystectomy(RC).
We enrolled 141 patients with urothelial carcinoma after radical cystectomy. ROC curve was used to determine the optimal cutoff values of FIB and PLR. The FIB and PLR were divided into the high-level group and the low-level group. If one indicator was high-level or both indicators were high-level, a combination score 1 (S1) was defined. If both indicators were low-level, a combination score 0 (S0) was defined. One-way analysis of variance and non-parametric tests were used to analyze the characteristics of patients, the Kaplan-Meier method was used for univariate survival analysis, the Log rank method was used for testing, and the Cox proportional hazards model was used for multivariate regression analysis.
The optimal cutoff values for FIB and PLR were 3.43 and 110.54, respectively. FIB level was closely related to T stage, pathological grade and tumor size (all P < 0.05), and PLR level was closely related to pathological grade and tumor size (P < 0.05). The preoperative combination score was closely related to T stage, N stage, pathological grade and tumor size (all P < 0.05). Combination score, T stage, tumor size, FIB and PLR were important factors affecting the prognosis. Combination score (P=0.019), T stage (P=0.021) and FIB (P=0.010) were independent risk factors for the prognosis.
The combination score is an independent risk factor for overall survival of patients undergoing radical cystectomy. It can be used as a new indicator for predicting the tumor progression and prognosis of patients with bladder cancer.
| [1] |
Dutta SC, Smith Jr JA, Shappell SB, et al. Clinical under staging of high risk nonmuscle invasive urothelial carcinoma treated with radical cystectomy[J]. J Urol, 2001, 166(2): 490-493. doi: 10.1016/S0022-5347(05)65969-1
|
| [2] |
Ark JT, Keegan KA, Barocas DA, et al. Incidence and predictors of understaging in patients with clinical T1 urothelial carcinoma undergoing radical cystectomy[J]. BJU Int, 2014, 113(6): 894-899. doi: 10.1111/bju.12245
|
| [3] |
Huang J, Yuan Y, Wang Y, et al. Prognostic value of preoperative plasma fibrinogen level and platelet-to-lymphocyte ratio (F-PLR) in patients with localized upper tract urothelial carcinoma[J]. Oncotarget, 2017, 8(22): 36761-36771. doi: 10.18632/oncotarget.13611
|
| [4] |
Tanaka N, Kikuchi E, Matsumoto K, et al. Prognostic value of plasma fibrinogen levels in patients with localized upper tract urothelial carcinoma[J]. BJU Int, 2013, 111(6): 857-864. doi: 10.1111/j.1464-410X.2012.11353.x
|
| [5] |
Shinko D, Diakos CI, Clarke SJ, et al. Cancer-Related Systemic Inflammation: The Challenges and Therapeutic Opportunities for Personalized Medicine[J]. Clin Pharmacol Ther, 2017, 102(4): 599-610. doi: 10.1002/cpt.789
|
| [6] |
Lalosevic MS, Markovic PA, Stankovic S, et al. Combined Diagnostic Efficacy of Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Mean Platelet Volume (MPV) as Biomarkers of Systemic Inflammation in the Diagnosis of Colorectal Cancer[J]. Dis Markers, 2019, 2019: 6036979. http://www.onacademic.com/detail/journal_1000041641869899_1e28.html
|
| [7] |
Wu Y, Jiang M, Qin Y, et al. Single and combined use of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and carcinoembryonic antigen in diagnosing gastric cancer[J]. Clin Chim Acta, 2018, 481: 20-24. doi: 10.1016/j.cca.2018.02.027
|
| [8] |
Ma JY, Ke LC, Liu Q. The pretreatment platelet-to-lymphocyte ratio predicts clinical outcomes in patients with cervical cancer: A meta-analysis[J]. Med, 2018, 97(43): e12897. doi: 10.1097/MD.0000000000012897
|
| [9] |
唐红, 吴伟莉, 金凤, 等.外周血中性粒细胞及血小板与淋巴细胞的比值与局部晚期鼻咽癌预后及疗效的相关性[J].肿瘤防治研究, 2019, 46(1): 32-36. doi: 10.3971/j.issn.1000-8578.2019.18.0578
Tang H, Wu WL, Jin F, et al. Relationship of peripheral blood neutrophil/lymphocyte ration and platelet/lymphocyte ration with curative effect and prognosis of patients with locally advanced nasopharyneal carcinoma[J]. Zhong Liu Fang Zhi Yan Jiu, 2019, 46(1): 32-36. doi: 10.3971/j.issn.1000-8578.2019.18.0578
|
| [10] |
Kluth LA, Black PC, Bochner BH, et al. Prognostic and Prediction Tools in Bladder Cancer: A Comprehensive Review of the Literature[J]. Eur Urol, 2015, 68(2): 238-253. doi: 10.1016/j.eururo.2015.01.032
|
| [11] |
Alevizopoulos A, Tyritzis S, Leotsakos I, et al. Role of coagulation factors in urological malignancy: A prospective, controlled study on prostate, renal and bladder cancer[J]. Int J Urol, 2017, 24(2): 130-136. doi: 10.1111/iju.13271
|
| [12] |
Liu J, Li D, Cao L, et al. Elevated preoperative plasma fibrinogen level is an independent predictor of malignancy and advanced stage disease in patients with bladder urothelial tumors[J]. Int J Surg, 2016, 36(Pt A): 249-254. http://www.sciencedirect.com/science/article/pii/S1743919116310159
|
| [13] |
Sørensen B, Larsen OH, Rea CJ, et al. Fibrinogen as a hemostatic agent[J]. Semin Thromb Hemost, 2012, 38(3): 268-273. doi: 10.1055/s-0032-1309287
|
| [14] |
Roche Y, Pasquier D, Rambeaud JJ, et al. Fibrinogen mediates bladder cancer cell migration in an ICAM-1-dependent pathway[J]. Thromb Haemost, 2003, 89(6): 1089-1097. doi: 10.1055/s-0037-1613412
|
| [15] |
Bagante F, Tran TB, Postlewait LM, et al. Neutrophil-lymphocyte and platelet-lymphocyte ratio as predictors of disease specific survival after resection of adrenocortical carcinoma[J]. J Surg Oncol, 2015, 112(2): 164-172. doi: 10.1002/jso.23982
|
| [16] |
Song W, Tian C, Wang K, et al. Preoperative platelet lymphocyte ratio as independent predictors of prognosis in pancreatic cancer: A systematic review and meta-analysis[J]. PLoS One, 2017, 12(6): e0178762. doi: 10.1371/journal.pone.0178762
|
| [17] |
Zhang GM, Zhu Y, Luo L, et al. Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy[J]. Tumour Biol, 2015, 36(11): 8537-8543. doi: 10.1007/s13277-015-3613-x
|
| [18] |
Zheng J, Cai J, Li H, et al. Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio as Prognostic Predictors for Hepatocellular Carcinoma Patients with Various Treatments: a Meta-Analysis and Systematic Review[J]. Cell Physiol biochem, 2017, 44(3): 967-981. doi: 10.1159/000485396
|
| [19] |
Tran E, Robbins PF, Rosenberg SA. 'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations[J]. Nat Immunol, 2017, 18(3): 255-262. http://smartsearch.nstl.gov.cn/paper_detail.html?id=6e6a52d2296bdc7eb36a47892503d3a5
|
| [20] |
Zhou X, Du Y, Huang Z, et al. Prognostic value of PLR in various cancers: a meta-analysis[J]. PLoS One, 2014, 9(6): e101119. doi: 10.1371/journal.pone.0101119
|
| [21] |
Singh R, Mishra MK, Aggarwal H. Inflammation, Immunity, and Cancer[J]. Mediators Inflamm, 2017, 2017: 6027305.
|
| [22] |
Wagner DD. New links between inflammation and thrombosis[J]. Arterioscler Thromb Vasc Biol, 2005, 25(7): 1321-1324. doi: 10.1161/01.ATV.0000166521.90532.44
|
| [23] |
Jain S, Harris J, Ware J. Platelets: linking hemostasis and cancer[J]. Arterioscler Thromb Vasc Biol, 2010, 30(12): 2362-2367. doi: 10.1161/ATVBAHA.110.207514
|
| [24] |
Palumbo JS, Talmage KE, Massari JV, et al. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells[J]. Blood, 2005, 105(1): 178-185. doi: 10.1182/blood-2004-06-2272
|
This work is licensed under a Creative Commons Attribution 3.0 License.
Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号
Supported by: Beijing Renhe Information Technology Co., Ltd. 
DownLoad: