| Citation: |
HU Gen, LI Wei, SHAO Guoyi, ZHANG Xian. Predictive Effect of Preoperative Platelet-lymphocyte Ratio on Prognosis of Patients with Gastric Stromal Tumor[J]. Cancer Research on Prevention and Treatment, 2018, 45(7): 479-482. DOI: 10.3971/j.issn.1000-8578.2018.17.1428
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To assess whether preoperative platelet-lymphocyte ratio(PLR) is an effective prognostic marker for gastric stromal tumor(GST) patients.
We retrospectively analyzed the clinical data of 92 patients with gastric stromal tumor. The PLR data of peripheral blood samples on the third day before surgery and immunohistochemistry results of all patients were collected. According to preoperative PLR, the patients were divided into low PLR group(PLR < 130, n=38) and high PLR group(PLR≥130, n=54). The survival of GST patients was compared between two groups and the relationship of clinical pathological characteristics with overall survival and postoperative recurrence-free survival were analyzed.
The preoperative PLR was related to mitotic?gures(χ2=5.95, P=0.015). The recurrence-free survival of the patients with high PLR was lower than that with low PLR before operation(χ2=6.17, P=0.018). The recurrence-free survival was associated with preoperative PLR, adjuvant treatment with imatinib, NIH risk category, mitotic?gures and tumor size in univariate analysis(P < 0.05). The preoperative PLR was independent prognostic indicator for recurrence-free survival of GST patients in Cox multivariate analysis (P < 0.05).
Preoperative PLR may be an independent prognostic factor for patients with gastric stromal tumor. High PLR before operation may indicate poor prognosis.
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