Objective To investigate the effects of radical surgery, neoadjuvant chemotherapy combined with radical surgery and concurrent chemoradiotherapy combined with radical surgery on the survival and postoperative complications of patients with stageⅠb2 andⅡa2 cervical cancer.
Methods We retrospectively analyzed the clinical data of 140 patients with stageⅠb2 and Ⅱa2 cervical cancer, 48 patients were treated with radical surgery alone (group A), 59 patients were treated with neoadjuvant chemotherapy combined with radical surgery (group B) and 33 patients were treated with concurrent chemoradiotherapy combined with radical surgery (group C). The intraoperative and postoperative clinical indicators, local invasion and lymph node metastasis rate, postoperative complication rate, median overall survival, and 1-, 2-, and 3-year survival rates were compared among three groups.
Results There was no significant difference in the time of surgery and total hospital stay among the three groups (P > 0.05). The bleeding volume, postoperative vessel and muscle invasion rate and lymph node metastasis rate in group C were significantly lower than those in group A and B (P < 0.05). Postoperative neurological invasion rate, postoperative complication rate, median overall survival and postoperative 1-, 2- and 3-year survival rates showed no significant difference among three groups (P > 0.05). Group B was divided into radiotherapy group (n=28), chemotherapy group (n=13) and chemoradiotherapy group (n=18) according to preoperative treatment. The 3-year survival rate of radiotherapy group was significantly higher than those of chemotherapy group and radiotherapy group (P < 0.05).
Conclusion The patients with stageⅠb2 andⅡa2 cervical cancer in three groups have similar survival condition and postoperative complications. However, concurrent chemoradiotherapy combined with radical surgery could reduce the surgical trauma, local postoperative invasion and lymph node metastasis rate.
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