Objective To observe the efficacy and side effects of induction chrono-chemotherapy combined with concurrent Lobaplatin chemoradiotherapy on locally advanced head and neck squamous cell carcinoma patients.
Methods Thirty patients with locally advanced head and neck squamous cell carcinoma were treated with TPF regimen induction chrono-chemotherapy followed by concurrent lobaplatin chemoradiotherapy.
Results The median follow-up was performed for 23 months. The effective rate after chemotherapy was 77%. That after simultaneous radiotherapy and chemotherapy was 93%. The overall survival rate, progression-free survival rate, local recurrence-free survival rate and distant metastasis-free survival rates of one year were 83.3%, 83.3%, 89.4% and 96.3%; those of two years were 71.6%, 68.4%, 73.4% and 86%, those of three years were 65.1%, 62.2%, 66.8% and 78.2%, respectively. The main toxicities of introduction chemotherapy were 3-4 grade of platelet reduction in one case, 3-4 grade of white blood cells reduction in seven cases, and 3-4 grade of neutropenia reduction in nine cases. The main toxicities of concurrent chemoradiotherapy were 3-4 grade of oral mucositis in four cases, 3-4 levels of thrombocytopenia in seventeen cases, 3-4 grades of leukopenia in twelve cases and 3-4 grade of neutropenia reduction in ten cases.
Conclusion The clinical efficacy of TPF regimen induction chrono-chemotherapy combined with concurrent Lobaplatin chemoradiotherapy is good, with tolerated side effects, but still need to expand the number of cases for long-term follow-up study.
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