Prognostic Factors for Extragastrointestinal Stromal Tumors Patients

Objective To explore clinical features and prognostic factors of extragastrointestinal stromal tumors(EGSTs). Methods We retrospectively analyzed clinicopathological data of 35 EGSTs patients admitted from January 2006 to May 2011 in Henan Tumor Hospital by SPSS17.0. Kaplan-Meier and Cox regression(forward stepwise regression) analysis were used to evaluate the prognostic factors(P<0.05). Results 1-, 2- and 3-year survival rates of all EGST patients were 81.6%, 57.3% and 35.3%; 18 patients (51.4%) with R0 resection developed recurrence or metastasis. Cox regression analysis showed that the surrounding tissue invasion (RR: 3.386, 95% CI: 1.142-10.044), tumor recurrence or metastasis (RR: 2.269, 95% CI: 1.055-4.880), tumor hemorrhage necrosis (RR: 3.015,95%CI: 1.120-4.880) and tumor rupture (RR: 8.085,95%CI: 2.517-25.967) were independent prognostic factors. Conclusion EGIST symptoms are dormant and difficult to diagnose, with large volume at first. Surrounding tissue invasion, tumor recurrence or metastasis, tumor hemorrhage necrosis and rupture are independent prognostic factors.