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ZHANG De-cai, ZHANG Jing-hua, WANG Ping, HE Jin, LIU Yuan-ting, MA Jie, NIU Feng-ling. Id1 mRNA Expression in Breast Cancer and Its Relation to Clinicopathological Features[J]. Cancer Research on Prevention and Treatment, 2011, 38(07): 780-783. DOI: 10.3971/j.issn.1000-8578.2011.07.014
Citation: ZHANG De-cai, ZHANG Jing-hua, WANG Ping, HE Jin, LIU Yuan-ting, MA Jie, NIU Feng-ling. Id1 mRNA Expression in Breast Cancer and Its Relation to Clinicopathological Features[J]. Cancer Research on Prevention and Treatment, 2011, 38(07): 780-783. DOI: 10.3971/j.issn.1000-8578.2011.07.014

Id1 mRNA Expression in Breast Cancer and Its Relation to Clinicopathological Features

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  • Received Date: May 18, 2010
  • Revised Date: October 14, 2010
  • ObjectiveTo investigate the expression of inhibitor of differentiation/DNA binding 1(Id1) in breast cancer tissue and its relation to clinicopathological and other molecular parameters. Methods The mRNA expression of Id1 in tissue and MCF -7 cell line of breast cancer were detected by fqRT-PCR.The protein expression of Id1, VEGF in 48 cases of breast carcinoma and 20 cases of breast fibroadenoma tissues of breast were detected by SABC immunohistochemistry. ResultsBy Real-time RT-PCR method,the 2-ΔCT values of the breast carcinoma tissue and breast fibroadenoma tissue were (3.4581±1.3644) and (1.1042±0.0125) respectively.The positive rates of Id1 were significantly higher in breast carcinoma than those in breast fibroadenoma tissues, there were significant difference between the two groups(P<0.05). Spearman rank correlation analysis revealed that the protein expression of Id1 was positively correlated with that of VEGF(r=0.303, P=0.037). No statistical correlation existed among the patients as grouped by age, lymph nodes metastasis, tumor size, histological grading, pTNM stages(P>0.05). ConclusionOver-expression of Id1 exists in the patients with breast cancer.The expression of Id1 is positively correlated with that of VEGF which may be related to blood vessel formation.
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