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广西人群中VEGF基因启动子区-460 T/C单核苷酸多态性与鼻咽癌的易感性

程小伟, 汪春林, 黄小庆, 张勇

程小伟, 汪春林, 黄小庆, 张勇. 广西人群中VEGF基因启动子区-460 T/C单核苷酸多态性与鼻咽癌的易感性[J]. 肿瘤防治研究, 2014, 41(10): 1125-1128. DOI: 10.3971/j.issn.1000-8578.2014.10.015
引用本文: 程小伟, 汪春林, 黄小庆, 张勇. 广西人群中VEGF基因启动子区-460 T/C单核苷酸多态性与鼻咽癌的易感性[J]. 肿瘤防治研究, 2014, 41(10): 1125-1128. DOI: 10.3971/j.issn.1000-8578.2014.10.015
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CHENG Xiaowei, WANG Chunlin, HUANG Xiaoqing, ZHANG Yong. VEGF Gene Promoter Region-460 T/C Single Nucleotide Polymorphisms and Nasopharyngeal Carcinoma Susceptibility in Guangxi Population[J]. Cancer Research on Prevention and Treatment, 2014, 41(10): 1125-1128. DOI: 10.3971/j.issn.1000-8578.2014.10.015
Citation: CHENG Xiaowei, WANG Chunlin, HUANG Xiaoqing, ZHANG Yong. VEGF Gene Promoter Region-460 T/C Single Nucleotide Polymorphisms and Nasopharyngeal Carcinoma Susceptibility in Guangxi Population[J]. Cancer Research on Prevention and Treatment, 2014, 41(10): 1125-1128. DOI: 10.3971/j.issn.1000-8578.2014.10.015
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广西人群中VEGF基因启动子区-460 T/C单核苷酸多态性与鼻咽癌的易感性

  • 530021 南宁，广西医科大学第一附属医院放疗科

基金项目: 广西自然科学基金面上项目(2011GXNSFA018242)
详细信息
    作者简介:

    程小伟（1986-），男，硕士，医师，主要从事鼻咽癌基础与临床研究

    通讯作者:

    张勇，E-mail：zhangyonggx@163.com

  • 中图分类号: R739.62

VEGF Gene Promoter Region-460 T/C Single Nucleotide Polymorphisms and Nasopharyngeal Carcinoma Susceptibility in Guangxi Population

  • Department of Radiotherapy, Affiliated No.1 Hospital of Guangxi Medical University, Nanning 530021, China

摘要

    摘要
  • 摘要: 目的 探讨血管内皮生长因子(vascular endothelial growth factor, VEGF) 基因启动子区-460 T/C单核苷酸多态性（SNP）在广西人群中与鼻咽癌发生发展的易感性。方法 鼻咽癌组240例，健康组245例。采用聚合酶链式反应（PCR），直接测序法检测两组人群VEGF-460 T/C单核苷酸的多态性。多元Logistic回归分析校正混杂因素，对VEGF-460 T/C基因多态性与鼻咽癌易感性进行相关统计学分析。结果 VEGF-460 T/C基因多态性分布符合Hardy-Weinberg平衡定律；VEGF-460位点T/T、T/C+C/C基因型在病例组中的频率分别为52.9%、47.1%，在对照组中的频率分别为：63.3%、36.7%，差异有统计学意义（χ2=5.335，P=0.021）。鼻咽癌组中VEGF-460 T/C SNP C等位基因频率（27.5%）明显高于对照组（20.6%），差异有统计学意义（χ2=6.303，P=0.012）。与T等位基因相比，携带有C 等位基因的基因型可增加鼻咽癌发病风险(OR=1.458，95%CI：1.115~1.952)；与T/T基因型相比，携带有C等位基因的基因型（T/C+C/C）能增加淋巴结转移的风险（OR=2.214，95%CI：1.276~3.842，P=0.038）。结论 VEGF基因启动子区-460 T/C单核苷酸多态性与鼻咽癌易感性显著相关。

     

    Abstract: Objective To explore the relationship between vascular endothelial growth factor(VEGF) gene promoter region-460 T/C single nucleotide polymorphisms(SNP) and nasopharyngeal carcinoma(NPC) susceptibility in Guangxi population. Methods We analyzed SNP of VEGF-460 T/C in 240 patients with NPC and 245 healthy controls, using polymerase chain reaction(PCR) sequence specific primers method. The association of the polymorphism with NPC susceptibility was determined by multivariate logistic regression analysis after mixed factors revision. Results Genotypic distributions of VEGF-460 T/C polymorphisms were in Hardy-Weinberg equilibrium. The distribution of VEGF-460 T/T(52.9%) and T/C+C/C(47.1%) differed from those(63.3%,36.7%) in control group(χ2=5.335，P=0.021). Compared with control group(20.6%), the frequency of C allele in NPC group(27.5%) was significantly higher(χ2=6.303，P=0.012). Compared with T allele, the C allele might increase the risk of nasopharyngeal carcinoma (OR=1.458，95%CI:1.115~1.952). Furthermore, compared with genotype T/T, the genotype T/C+C/C containing C allele increased the risk of lymphatic metastasis （OR=2.214，P=0.038）. Conclusion There is significant correlation between VEGF-460 T/C polymorphism and NPC susceptibility.

     

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出版历程
  • 收稿日期:  2013-08-18
  • 修回日期:  2013-11-12
  • 刊出日期:  2014-10-24

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