Advanced Search
FU Ze-xian, MENG Fan-jie, LI Bao-dong, LI Dong-bin, XIE Shao-jian, CHEN Xiao-he, FAN Xiao-yan, CAI Jian-hui. Clinical Significance of FoxP mRNA Expression in CD4 CD25 Regulatory T Cells Isolated from Patients with Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 935-936. DOI: 10.3971/j.issn.1000-8578.57
Citation: FU Ze-xian, MENG Fan-jie, LI Bao-dong, LI Dong-bin, XIE Shao-jian, CHEN Xiao-he, FAN Xiao-yan, CAI Jian-hui. Clinical Significance of FoxP mRNA Expression in CD4 CD25 Regulatory T Cells Isolated from Patients with Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 935-936. DOI: 10.3971/j.issn.1000-8578.57
shu

Clinical Significance of FoxP mRNA Expression in CD4 CD25 Regulatory T Cells Isolated from Patients with Gastric Cancer

  • Department of Gatrointestinal Surgery, The Second Affiliated Hospital, Hebei Medical University, Shijiazhuang 050000, China( * Present : Department of General Surgery, The Affiliatecl Hospital of Hebei University of Engineering)

More Information
  • Corresponding author:

    CAI Jian-hui

  • Received Date: December 25, 2006
  • Revised Date: August 09, 2007
    Graphical Abstract
    • Abstract
  • Objective 　To investigate the content s of CD4 CD25 T cells and the expression of FoxP mRNA in these Treg cells in peripheral blood of the patients with gast ric cancer and to characterize their clinical significance. Methods 　By using flow cytometry, the levels of CD4 CD25 T cells in peripheral blood of 20 preoperative patient s with gastric cancer were determined. RT-PCR techniques were used to detect the expression of FoxP mRNA in these Treg cells, and the results were analyzed statistically in comparison with that of 20 healthy volunteers. Results 　The percentage of CD4 CD25 T cells in total CD4 T cells isolated f rom the patient s with gastric cancer was (12. 76 ±0. 46) %, in comparison, it was (6. 81 ±0. 66) % in those f rom healthy volunteers. It was obviously different between Treg cells amount of gastric patients and that of volunteers ( P < 0. 01) . The FoxP mRNA expression of Treg cells in the patients with gastric cancer (0. 84 ±0. 02) %〕was significantly higher than that in healthy volunteers 〔(0. 76 ±0. 03) %, ( P<0. 05) . Conclusion 　The levels of CD4 CD25 T cells in peripheral blood and the FoxP mRNA expression of Treg cells in gast ric cancer patient s were increasing significantly. FoxP genes may play a pivotal role in regulating the function of Treg cells in self-tumor immunity of the patient s with gastric cancer.
    • FullText(HTML)
    • References (0)
    • Related Articles

  • Related Articles

    [1]TIAN Hongjuan, ZHANG Renle, QIAO Yanhong, ZHANG Dengxia, LIU Bei. Application of New Single-cell Analysis Technology——Cytometry by Time-of-flight in Treatment of Leukemia[J]. Cancer Research on Prevention and Treatment, 2021, 48(2): 209-213. DOI: 10.3971/j.issn.1000-8578.2021.20.0662
    [2]ZHANG Suxin, LIU Zhemin, DUAN Yuqin, CHEN Yanping, GUO Lantao, LI Tianke, CHEN Zhong. Clinical of CD4+CD25+Foxp3+ Regulatory T Cells Expression in Peripheral Blood and Cancer Tissues of Oral Squamous Cell Carcinoma Patients[J]. Cancer Research on Prevention and Treatment, 2013, 40(11): 1041-1045. DOI: 10.3971/j.issn.1000-8578.2013.11.007
    [3]ZHOU Wei, YU Jie, LIU Li, LIU Zhong-ping. Changes of the CD4~+CD25~+Foxp3~+ Treg Cells in Peripheral Blood in Patients with NSCLC with Gemzar and Cisplatin Regimen[J]. Cancer Research on Prevention and Treatment, 2008, 35(05): 343-346. DOI: 10.3971/j.issn.1000-8578.2839
    [4]ZHANG Meng-xian, HAN Na, YU Shi-ying. Prognostic Significance of Flow-cytometric DNA Anaysis in Locally Advanced Cervical Squamous Carcinoma[J]. Cancer Research on Prevention and Treatment, 2007, 34(12): 940-943. DOI: 10.3971/j.issn.1000-8578.54
    [5]CHEN Sheng-li, QUAN Yi, XU Yan-li, WUANG Zi-cheng, CHEN Guo-dong, DU Qing-hua. Flow Cytometry Research on Tumor Cell Apoptosis of Rabbit VX2 Liver Implanted Tumor in Earlier Period After Interventional Treatment[J]. Cancer Research on Prevention and Treatment, 2006, 33(12): 853-855. DOI: 10.3971/j.issn.1000-8578.365
    [6]ZUO Wen-shu, WEI Ling, SONG Xian-rang, WANG Xing-wu, YU Zhi-yong, BI Ye. The Analysis of MGMT and GST-π Protein Expression Detected by Flow Cytometry in Breast Carcinoma Tissues and Corresponding Para-Carcinoma Tissues[J]. Cancer Research on Prevention and Treatment, 2006, 33(08): 558-560. DOI: 10.3971/j.issn.1000-8578.1832
    [7]DU Yun, WANG Xiao ling, WU Guo xiang, WANG Yong jun, YANG Hui chai, ZUO Lian fu. Expression and Significance of COX-2 and iNOS in Esophageal Cancer by Flow Cytometry[J]. Cancer Research on Prevention and Treatment, 2004, 31(08): 482-484. DOI: 10.3971/j.issn.1000-8578.3179
    [8]XUE Ying-wei, GENG Jing-zhu, LIU Xiao-ming, et al, . The Analysis of Gastric Carcinoma Cell by Flow Cytome try and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2000, 27(03): 216-217. DOI: 10.3971/j.issn.1000-8578.2815
    [9]Zhou Zhenying, . Flow cytometric Study of Ploliferous Characteristics in Para-cancer Tissue[J]. Cancer Research on Prevention and Treatment, 1996, 23(1): 23-27.
    [10]Zho Zhenying, . Comparative study on flow cytometry,hlstopathology and endoscopy in tumor high-risk regional people[J]. Cancer Research on Prevention and Treatment, 1994, 21(3): 154-156.

Catalog

    Get Citation
    PDF
    XML
    Article views (2159) PDF downloads (666) Cited by()
    Turn off MathJax
    Article Contents
    Abstract
    Related Articles

    Download Center

    Links

    Contact Us

    Address：116 Zhuodaoquan South Road,
    Hongshan District, Wuhan（430079）

    Tel：027－87670126

    Email：zlfzyjzz@vip.163.com

    This work is licensed under a Creative Commons Attribution 3.0 License.

    Email Alert RSS
    Total visits：11869982 Visits today：16221

    Copyright © Editorial Department of Cancer Prevention Research 鄂公网安备 42011102005013号 鄂ICP备2022015867号

    Supported by: Beijing Renhe Information Technology Co., Ltd.  Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return