Advanced Search
LI Gao-feng, WU De-Hua, LI Gui-Sheng, CHEN Long-hua. Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2007, 34(07): 520-523. DOI: 10.3971/j.issn.1000-8578.2427
Citation: LI Gao-feng, WU De-Hua, LI Gui-Sheng, CHEN Long-hua. Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2007, 34(07): 520-523. DOI: 10.3971/j.issn.1000-8578.2427

Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy

More Information
  • Corresponding author:

    CHEN Long-hua

  • Received Date: July 23, 2006
  • Revised Date: January 01, 2007
  • Objective  To evaluate ret rospectively the correlative clinical and dosimetric factors resulted in acute esophageal toxicity in the course of the t reatment of the patient s with stage Ⅲ non-small cell lung cancer with three-dimensional conformal radiotherapy. Methods  Seventy six patients with NSCLC were treated with 3D-CRT between august 2002 and december 2005. The clinic factors and treatment parameters were collected and coded. Acute esophageal toxicities were graded. All factors correlating with acute esophageal toxicity were analyzed. Results  27 patients (35. 53 %) out of the seventy-six patient s had developed acute esophageal toxicity according to RTOG scores. The acute esophageal toxicities were graded : I-15 、II-6 、Ⅲ-6. Spearman rank correlation coefficients had showed that chemotherapy, percentages of esophagus volume receiving > 50 Gy(V50 ), the average dose to the esophagus, correlated with acute esophageal toxicity. Binary logistic regression analysis showed chemotherapy, esophageal V50, were the independent risk factors of acute esophageal toxicity. Conclusion  Concurrent chemotherapy and the maximal esophageal point dose ≥50 Gy significantly related to the acute esophageal toxicity in patients with stage III NSCLC treated with 3D-CRT.
  • Related Articles

    [1]WANG Sheng, WANG Cailian, FAN Lihua. Correlation Between Dose Volume Parameters and Radiation Pneumonitis in Elderly Patients with Esophageal Cancer After Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2021, 48(2): 173-177. DOI: 10.3971/j.issn.1000-8578.2021.20.1323
    [2]WANG Yuxiang, TIAN Dandan, QIU Rong, TIAN Xiuming, WANG Lili. Influence Factors for Radiation Pneumonitis in Stage Ⅲ Non-small Cell Lung Cancer Patients Treated with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2014, 41(12): 1307-1312. DOI: 10.3971/j.issn.1000-8578.2014.12.012
    [3]WEI Xuan, LI Jiangfeng, ZHOU Qiongfang, LI Yang, LIAO Xiaowen, ZENG Qian, NIU Daoli. Dosimetric Factors Analysis of Radiation-induced Lung Damage in Non-small Cell Lung Cancer Patients Treated with Three-dimentional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2014, 41(07): 762-765. DOI: 10.3971/j.issn.1000-8578.2014.07.016
    [4]WANG Yu-xiang, ZHU Shu-chai, QIU Rong, SU Jing-wei, SHEN Wen-bin. Prognosis of T4 Esophageal Carcinoma with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2011, 38(06): 690-694. DOI: 10.3971/j.issn.1000-8578.2011.06.023
    [5]WANG Yu-xiang, ZHU Shu-chai, SU Jing-wei, LI Juan, SHEN Wen-bin. Prognostic Analysis of Three-dimensional Conformal Radiotherapy (3D-CRT) for Cervical and Upper-thoracic Esopageal Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(01): 93-97. DOI: 10.3971/j.issn.1000-8578.2011.01.027
    [6]ZHOU Shao-bing, LIU Yang-chen, GAO Fei, YE Hong-xun, ZHAO Ying, YIN Xiao-xiang. Chemotherapy Combined with Three Dimensional Conformal Radiotherapy for Postoperative Mediastinum Lymphonode Metastasis from Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(10): 1189-1191. DOI: 10.3971/j.issn.1000-8578.2010.10.024
    [7]ZHANG Bin, QIAO Tian-kui. Predictors of Pulmonary LesionInducedby Three Dimensional Conformal Radiotherapy Combined with Chemotherapy of NP forⅢStage Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(05): 578-581. DOI: 10.3971/j.issn.1000-8578.2010.05.024
    [8]CAO Feng-jun, CHEN Ping, PAN Dong-feng, WEI Juan, CAI xiao-jun. Combined Three Dimensional-conformal Radiotherapy(3DCRT) and Chemotherapy Treat Local-recurrence Non-small Cell Lung Cancer(NSCLC) After Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2006, 33(06): 450-452. DOI: 10.3971/j.issn.1000-8578.2306
    [9]ZHOU Shao-bing, LIU Yang-chen, GAO fei, YE Hong-xun, ZHAO Ying, YIN Xiao-xiang. Chemotherapy and Late Course Accelerated Hyperfrationation Plus Three Dimensional Conformal Radiotherapy for Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2005, 32(08): 515-516. DOI: 10.3971/j.issn.1000-8578.1813
    [10]ZHOU Tong chong, LIN Xiao dan, . Three Dimensional Conformal Hypofractionated Hige-dose Radiotherapy Combined with Chemotherapy for Stage Ⅲ Non-small-cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2004, 31(08): 498-500. DOI: 10.3971/j.issn.1000-8578.3173

Catalog

    Article views (2003) PDF downloads (598) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return