LI Gao-feng, WU De-Hua, LI Gui-Sheng, CHEN Long-hua. Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2007, 34(07): 520-523. DOI: 10.3971/j.issn.1000-8578.2427
Citation:
LI Gao-feng, WU De-Hua, LI Gui-Sheng, CHEN Long-hua. Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2007, 34(07): 520-523. DOI: 10.3971/j.issn.1000-8578.2427
LI Gao-feng, WU De-Hua, LI Gui-Sheng, CHEN Long-hua. Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2007, 34(07): 520-523. DOI: 10.3971/j.issn.1000-8578.2427
Citation:
LI Gao-feng, WU De-Hua, LI Gui-Sheng, CHEN Long-hua. Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy[J]. Cancer Research on Prevention and Treatment, 2007, 34(07): 520-523. DOI: 10.3971/j.issn.1000-8578.2427
Correlative Cl inical and Dosimetric Factors Resulted in Acute Esophageal Toxicity in Course of Treatment of Patients with Stage Ⅲ Non-small Cell Lung Cancer with Three-dimensional Conformal Radiotherapy
1. Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;2. Department of Oncology, the fourth affiliated Hospital of Guangxi Medical University
Objective To evaluate ret rospectively the correlative clinical and dosimetric factors resulted in acute esophageal toxicity in the course of the t reatment of the patient s with stage Ⅲ non-small cell lung cancer with three-dimensional conformal radiotherapy. Methods Seventy six patients with NSCLC were treated with 3D-CRT between august 2002 and december 2005. The clinic factors and treatment parameters were collected and coded. Acute esophageal toxicities were graded. All factors correlating with acute esophageal toxicity were analyzed. Results 27 patients (35. 53 %) out of the seventy-six patient s had developed acute esophageal toxicity according to RTOG scores. The acute esophageal toxicities were graded : I-15 、II-6 、Ⅲ-6. Spearman rank correlation coefficients had showed that chemotherapy, percentages of esophagus volume receiving > 50 Gy(V50 ), the average dose to the esophagus, correlated with acute esophageal toxicity. Binary logistic regression analysis showed chemotherapy, esophageal V50, were the independent risk factors of acute esophageal toxicity. Conclusion Concurrent chemotherapy and the maximal esophageal point dose ≥50 Gy significantly related to the acute esophageal toxicity in patients with stage III NSCLC treated with 3D-CRT.
DownLoad: