Prognostic Analysis of Three-dimensional Conformal Radiotherapy (3D-CRT) for Cervical and Upper-thoracic Esopageal Cancer

Abstract:Objective To explore the effects and related prognostic factors of 3-dimensional conformal radiotherapy (3D-CRT) for cervical and upper-thoracic esophageal carcinoma. Methods One hundred and twenty three cases of cervical and upper-thoracic esophageal carcinoma treated with 3D-CRT were collected.2001 to August 2007 Local control rates, survival rates and its related prognostic factors were evaluated retrospectively with SSPS11.5 software. Results The 1,3 and 5year local control rates was 79.0%，50.1% and 49.5%，respectively. The 1-,3- and 5-year overall survival rate was 70.7%,35.9% and 21.7%, respectively. The median survival time was 24.5 months. With univariate analysis, the significant prognostic factors were the different biet, lesion length in barium esophagogram and CT image, the largest diameter of lesion in CT scanning image, T stage, N stage, clinical TNM stage, the immediate response, dose of radiotherapy and chemotherapy. Multivariate analysis revealed that the,lesion length in barium esophagogram, the clinical stage, dose of radiotherapy and chemotherapy were independent prognostic factors. Conclusion 3D-CRT can be considered as an effective and feasible approach for cervical and upper-thoracic esophageal cancer.Lesion length in barium esophagogram, the clinical stage, dose of radiotherapy and chemotherapy were important prognostic factors for cervical and upper-thoracic esophageal cancer.