Advanced Search
WANG Zhi-feng, LIU Qin-jiang, LIAO Shi-qi, GE Ting, YANG Rong. Contradiction and Non-correlation between NIS and TSHR Expression in Human Thyroid Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(08): 909-913. DOI: 10.3971/j.issn.1000-8578.2011.08.014
Citation: WANG Zhi-feng, LIU Qin-jiang, LIAO Shi-qi, GE Ting, YANG Rong. Contradiction and Non-correlation between NIS and TSHR Expression in Human Thyroid Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(08): 909-913. DOI: 10.3971/j.issn.1000-8578.2011.08.014

Contradiction and Non-correlation between NIS and TSHR Expression in Human Thyroid Cancer

More Information
  • Received Date: August 04, 2010
  • Revised Date: December 16, 2010
  • ObjectiveTo investigate the correlation between sodium/iodide symporter and thyroid stimulating hormone receptor expression in human thyroid cancer . Methods mRNA levels, quantified by real-time PCR, and protein evaluated by immunohistochemistry, were examined in surgical specimens of 18 normal thyroid tissues and 23 thyroid carcinoma tissues. ResultsThe NIS and TSHR mRNA levels of thyroid carcinoma were significantly lower than those of normal thyroid tissue and nodular goiter(P<0.005). In addition, there was a significant positive correlation between NIS and TSHR in normal thyroid samples (r=0.667, P=0.000), but no such correlation in thyroid carcinomas(r=0.222,P=0.376). The immunohistochemistry results showed that the NIS protein mainly located in cytoplasm, and TSHR protein mainly located in cytoplasm and cytomembrane .In thyroid carcinomas, the positive rates of NIS and TSHR protein were markedly higher than those in normal thyroid tissues(P<0.05). Through combined analysis of NIS mRNA concentrations and immunostaining scores, in the thyroid carcinomas, reduction of NIS mRNA expression with increment of intracellular protein was found in 74% (17/23) of the samples compared with normal tissues. ConclusionIn thyroid carcinomas, there were expressed contradiction and non-correlation between NIS and TSHR expression. NIS was not able to play the role of protein transporting and absorbing iodine as mainly located in cytoplasm, which was regarded as an important reason of radioiodine therapy failure for thyroid carcinoma.
  • Related Articles

    [1]CHEN Lijun, CHEN Jingqi, ZENG Bohang. Correlation of CD68+ Tumor-associated Macrophages Number with Ki-67 Expression and Prognosis of Patients with Primary Hepatocellular Carcinoma[J]. Cancer Research on Prevention and Treatment, 2016, 43(9): 774-778. DOI: 10.3971/j.issn.1000-8578.2016.09.009
    [2]LI Wen, FENG Yanlin. Valuation of SUVmax, Ki-67, p53 and EGFR in Predicting Effect of Neoadjuvant Chemotherapy on Triple-negative Breast Cancer Patients[J]. Cancer Research on Prevention and Treatment, 2016, 43(1): 45-47. DOI: 10.3971/j.issn.1000-8578.2016.01.010
    [3]YAN Su, LI Bin, MA Xuxiang, MA Yingcai, XIONG Yuanzhi, GUO Xinjian, MA Yubin, YU Pengjie, WU Junqi, XIE Dawei, ZHAO Junhui, WU Huixian. Clinicopathological Characteristics of Young Gastric Cancer Patients in Hehuang Valley[J]. Cancer Research on Prevention and Treatment, 2015, 42(05): 502-505. DOI: 10.3971/j.issn.1000-8578.2015.05.018
    [4]ZHANG Cui-cui, WANG Jing, LI Kai. Characteristics and Prognostic Analysis of 60 Young Patients with Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2011, 38(03): 274-277. DOI: 10.3971/j.issn.1000-8578.2011.03.009
    [5]LIANG Xu-dong, SHI Xiao-feng, JIA Zong-qi. Detection andSignificance of PTEN, NFκB andKi-67 in Gastric Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(03): 326-629. DOI: 10.3971/j.issn.1000-8578.2010.03.023
    [6]ZHONG Wei-ming, MA Li-ping, CAI Yong-lin, LIANG Wei, CHEN Wan-sheng, HUANG Zhuo, YU Hong, TAN Bi-fang. Relationship between Expression of Ki-67 Protein and Radiosensitivity of Nasopharyngeal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2010, 37(02): 195-196. DOI: 10.3971/j.issn.1000-8578.2010.02.019
    [7]SHI Guo-qing, ZHAO Kui, WANG Hong, LIU Mo-rong. Expression of Gastrin and Ki-67 in Gastric Cancer and Precancerous Pesions[J]. Cancer Research on Prevention and Treatment, 2009, 36(09): 756-758. DOI: 10.3971/j.issn.1000-8578.2009.09.011
    [8]HE Yan-jiao, LIU Zhao-xia, LI Hong-li, YU Jin, LI Guang. Expression and Significance of E-cadherin and Ki-67 in Colorectal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2007, 34(09): 699-702. DOI: 10.3971/j.issn.1000-8578.2529
    [9]ZHENG Lei, HAN Yue-wu. Antisense Oligodeoxyribonucleotide Target Ki-67 Inhibits Proliferation of Human Hepatocellucar Carcinoma Cell HEPG-7402 in Vitro[J]. Cancer Research on Prevention and Treatment, 2006, 33(12): 862-864. DOI: 10.3971/j.issn.1000-8578.354
    [10]DENG Jie, CAO Dun-wen, LIU Ming-qiu, ZHU Run-qing, CHEN Hong-lei, CHEN Dao-ying, WANG Ji-e. Expression of p73, PTEN and Ki-67 Proteins in Endometrioid Adenocarcinoma and Their Significance[J]. Cancer Research on Prevention and Treatment, 2006, 33(11): 811-813. DOI: 10.3971/j.issn.1000-8578.374

Catalog

    Article views (2789) PDF downloads (399) Cited by()

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return