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ZENG Tong-xia, MA Yan-qing, XU Li, CAI Jin-feng, LI Feng, HE Ling, QIN Jiang-mei. A 1:2 Case-control Study of Tap2/HLA-DR9 Gene Polymorphism with Esophageal Cancer in Kazakh[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 210-213. DOI: 10.3971/j.issn.1000-8578.2011.02.024
Citation: ZENG Tong-xia, MA Yan-qing, XU Li, CAI Jin-feng, LI Feng, HE Ling, QIN Jiang-mei. A 1:2 Case-control Study of Tap2/HLA-DR9 Gene Polymorphism with Esophageal Cancer in Kazakh[J]. Cancer Research on Prevention and Treatment, 2011, 38(02): 210-213. DOI: 10.3971/j.issn.1000-8578.2011.02.024

A 1:2 Case-control Study of Tap2/HLA-DR9 Gene Polymorphism with Esophageal Cancer in Kazakh

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  • Received Date: January 05, 2010
  • Revised Date: March 15, 2010
  • ObjectiveTo evaluate the association between Tap2379/Tap2665 genetic polymorphisms/ HLA-DR9 immune-associated gene and esophageal cancer (EC) in a high incidence Kazakh of Xinjiang. MethodsA case-control study was conducted with 194 cases of EC and 388 controls. Tap2379/Tap2665 genotypes were detected by PCR-RFLP and HLA-DR9 allele gene were identified by PCR.The conditional logistic regression model was performed in this study. ResultsTap2379 genotype frequencies of esophageal cancer group was different from the controls(χ2=18.247,P<0.05,OR=2.347,95%CI:1.587~3.471);Tap2665 genotype did not find this difference(χ2=2.175,P>0.05,OR=1.317,95%CI:0.919~1.899); HLA-DR9 allele positive of case group was different from the controls(χ2=13.443,P<0.05,OR=2.343,95%CI:1.486~3.693).Multivariate conditional logistic regression analysis showed: Tap2379 genetic polymorphisms/ HLA-DR9 gene and history of esophageal or stomach disease were risk factors of Kazakh esophageal cancer. The interaction analysis showed Tap2379 genetic polymorphisms with HLA-DR9 allele gene significantly increased risk to the development of esophageal cancer 5.302(95%CI:2.363~11.900). Conclusion Tap2379 genetic polymorphisms and HLA-DR9 allele gene are important risk for EC, Tap2665 genotype did not found this action. Tap2379 and HLA-DR9 showed an additive risk to develop esophageal carcinoma.
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