Abstract: Objective To investigate the effect of tumor local factors on the prognosis of non-metastasis esophageal squamous cell carcinoma(ESCC) patients. Methods We retrospectively analyzed the clinical data of 263 ESCC patients. The effects of barium meal length, GTV maximum diameter, GTV length and GTV volume on the prognosis of patients were analyzed. Results ROC curve analysis showed that the prognosis critical value of barium meal length, GTV maximum diameter, GTV length and GTV volume were 4.25, 1.80, 5.85 cm and 27.98 cm3, respectively. Univariate analysis showed that barium meal length(P=0.0004), GTV maximum diameter(P=0.0246), GTV length(P=0.0035) and GTV volume (P=0.0184) were the prognostic factors for survival rate; the barium meal length (P=0.0149) was the prognostic factor for local control rate. Multivariate analysis showed that barium meal length(P=0.0013), GTV maximum diameter(P=0.0047) and GTV length(P=0.0032) were the independent prognostic factors for survival rate; the barium me al length(P=0.0037) was the independent prognostic factor for local control rate. Conclusion The ba-rium meal length is the main prognosis factor for non-metastasis ESCC patients, so we suggest that the clinical physician must give enough attention and active treatment to the patients with long barium meal.