Abstract: Objective To compare the acute toxicities and nutritional status between non-metastasis nasopharyngeal carcinoma(NPC) patients treated by intensity-modulated radiotherapy(IMRT) combined with 40 mg/m² cisplatin alone concurrent chemotherapy weekly and those treated by IMRT with 80-100 mg/m² cisplatin every three weeks. Methods A retrospective clinical data analysis was conducted on 45 patients with non-metastatic NPC. Patients received 40 mg/m² cisplatin weekly or 80-100 mg/m2 cisplatin every three weeks, concurrently with IMRT. The National Cancer Institute Common Toxicity Criteria version 3.0 scale (CTCAE V3.0) was used to assess the chemotherapy and acute toxicities. The acute toxicities and nutritional status were analyzed statistically by t-test, Chi-Square test/Chi-Square Goodness-of-Fit test or Analysis of Variance (ANOVA). Results In 45 NPC patients treated by IMRT, 31 patients received 40 mg/m² cisplatin weekly and 14 patients received 80-100 mg/m2 cisplatin every three weeks concurrently chemotherapy. The grade 3-4 acute toxicity occurrence rates of xerostomia, pharyngodynia, oral mucositis, dermatitis, nausea, vomit and myelosuppression were 6.7%, 15.6%, 28.9%, 6.7%, 8.9%, 13.3% and 22.2%, respectively. Although the changes of BW, BMI, ALB, TP, BUN, Cr, Na⁺, K⁺, Ca²⁺ and Cl^- had no statistical difference between two groups after treatment(P＞0.05) by Gender stratification ANOVA, the change of ALB was closed to a statistical difference. Both groups of ALB, TP, Na+ and Cl- were decreased after treatment (P＜0.05), but BW and BMI in cisplatin weekly group were decreased more severely than those in cisplatin every three weeks group. Conclusion It seems that the nutritional status of cisplatin weekly group is decreased more generally than that of cisplatin every three weeks group, but without significant difference in two groups before and after treatment.