Abstract: Objective To evaluate the clinical effect of different treatment models on the prognosis and quality of life (QOL) of patients with stage ⅡB cervical cancer. Methods A total of 269 patients with stage ⅡB cervical cancer treated at Dept. of Gynecological Oncology of The Affiliated Tumor Hospital of Guangxi Medical University from January 1, 2000 to December 31, 2010 were retrospectively analysed and divided into 4 groups, Group 1: exclusive radiotherapy(43 cases), Group 2: concurrent chemoradiotherapy (96 cases), Group 3: neoadjuvant chemotherapy (NACT) or chemoradiotherapy plus radical hysterectomy and pelvic lymphadenectomy (76 cases), Group 4: Group3 followed adjuvant radiotherapy and/or chemotherapy(52 cases). The 5-year overall survival rate(OS), 5-year disease free survival rate(DFS) and QOL were compared and influence factors for survival were analyzed among 4 groups. Results Group 2 was with the best OS, however, Group 4 was with the worst OS. OS of Group 2 and 1 were better than those of Group 3 and 4 respectively, with no significant difference. OS of Group 2 and 3 were better than those of Group 1 and 4(P<0.05). QOL of both Group 1 and Group 2 were worse. Conclusion NACT or chemoradiotherapy plus surgery could improve OS, DFS and QOL of partial patients with stage ⅡB cervical cancer. More clinical trials are required to demonstrate the conclusion.