Abstract: Abstract:Objective To investigate the inhibitory effect of Angelica sinensis and Radix Sophorae Flavescentis Decoction (ARD) on H22 transplanted tumor and serum HIF1α and LDH in mice. Methods H22 hepatocellular transplantation tumor models were established to be randomly divided into the control, cisplatin, ARD and ARD plus cisplatin groups. General state of KM mice was observed to calculate effective bodyweight changes. Tumor inhibition rate, q value, as well as indexes of tumor, liver, spleen, kidney and thymus were calculated. Blood routine was applied to determine white blood cell count. Serum HIF1α and LDH were determined by ELISA and biochemistry method separately. Results The general states of ARD plus cisplatin group and ARD group were better than those of cisplatin group and control group. The tumor weights of treatment groups were lighter than that of control group( P＜0.05). The tumor inhibiting rate of ARD plus cisplatin group was higher than those of ARD group and cisplatin group. ARD plus cisplatin had Synergistic effect. Increase of bodyweight minus tumor weight, and indexes of spleen and thymus in ARD group were higher than those in cisplatin group ( P＜0.05). Serum level of HIF-1α in control group was higher than those of ARD group and ARD plus cisplatin group( P＜0.05). LDH activity in cisplatin group was higher than those in other treatment groups. ( P＜0.05)． Conclusion ARD can inhibit the growth of transplanted tumor in mice, provide positive effect and reduce the side effect of cisplatin chemotherapy, which might have the relation with reducing HIF-1α concentration and LDH activity to a certain degree.