Abstract: Objective To observe the protective effects of monosialoganglioside on oxaliplatin-induced sensory neurotoxicity. Methods Sixty-eight patients receiving oxaliplatin-based chemotherapy were randomly divided into treatment group(n=38, monosialoganglioside, 40 mg/d, 3d) and control group(n=30, fursultiamine, 50 mg, orally bid, three times a day, continuous medication) to prevent oxaliplatin-induced sensory neurotoxicity. The acute and cumulative sensory neurotoxicity, chemotherapeutic effect and adverse reactions in two groups after chemotherapy were assessed. Results The incidence of acute sensory neurotoxicity in monosialoganglioside group was significantly lower than that in control group(5.3% vs. 26.7%, P=0.013). The incidence of cumulative sensory neurotoxicity in control group was 63.3%(19/30), with grade 1-2 in 15 cases, grade 3 in 3 cases and grade 4 in 1 case, signifi cantly higher than that 15.8%(6/38) in monosialoganglioside group, with grade 1-2 in 6 cases. There was no statistically signifi cant difference in chemotherapy-induced adverse reaction, ORR, DCR or mPFS between both groups. Conclusion Monosialoganglioside is an effective neuroprotectant against oxaliplatin-induced sensory neurotoxicity without infl uencing in chemotherapeutic effi cacy or chemotherapy-induced adverse reaction.