甲状腺癌、腺瘤及正常甲状腺组织女性激素受体检测的临床病理研究
Pathological study on expression of estrogen and progesterone in thyroid carcinoma, adenoma and normal tissues
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摘要: 采用酶联亲和组化法于石蜡切片对67例甲状腺癌、20例腺瘤及33例瘤旁正常甲状腺组织进行了雌激素受体(ER)和孕激素受休(PgR )检浏.结果显示:在腺癌中ER, PgR阳性表达明显高于腺瘤及正常组织（P<0. O1) .癌组织中乳头状癌阳性率最高，滤泡状癌次之，未分化及其它癌最低.40岁以前癌组织中PgR阳性率高于40岁以后(P<0. 05).女性癌组织中PgR阳性率高于男性(P<0. 05) .提示:ER, PgR检测有可能成为判断癌组织分化及枯计预后的一项新的参考指标.Abstract: Abstract Paraffin-embedded section from 67 cases with thyroid carcinoma, 20 cases with thyroid adenoma and 33 cases of normal thyroid tissues were assayed by enzyme-linked histochemical technique for the expression of ER (estrogen receptor) and PgR (Progesterone receptor). Results showed that the expression of receptor in carcinoma was much higher than that of adenoma and normal tisses (P<0. 01). The positive rate of ER and PgR in papillary carcinoma was highest, followed by follicular carcinoma, undifferentiated carcinoma and orther kinds of thyroid cancer. The PgR positive rate of the patients under the age of 40 was higher than those over 40 (P<0. 05). The PgR positive rate of female was higher than of male (P<0. 05). The study suggested that the PgR expression maybe offered a new reference for the differentiation of the cancer and grognosis of patients.
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1 余建军，等.甲状腺乳头状癌的生长与女性激素受体及血清激素水平相关的研究.中国肿瘤临床,1992,1:14 2 王翠芳，等.滤泡上皮源性甲状腺癌的性类固醉激素受体的临床病理研究.实用肿瘤,1993,3 :145 3 刘尚廉，等.乳腺痛雌激素受体酶联雌二醉组化标记法.月中瘤,1986,6:104 4 Hitoshi M, et al. Sex Hormone Receptors in HumanThyroid Tissue.Cancer, 1990, 66:1759 5 Yuji M, et al. Estrogen and Estrogen Receptors in Thy-roid Carcinomas.Journal of Surgical Chtcology , 1991, 47，1656 Cunninghan MP ，et al. Survival diacriminata for differ- entiated thyroidcancer. Am J Surg, 1990, 160:344
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