血清cPSA对前列腺癌诊断价值的研究

The study of diagnosis of complexed prostate-specific antigen for prostate cancer

摘要: 目的　探讨血清中结合前列腺特异性抗原 (c PSA)在前列腺癌 (PCa)诊断中的临床价值。方法　用磁微粒子免疫化学发光法测定 72例良性前列腺增生 (BPH)患者和 38例PCa患者c PSA、t PSA, 并计算c PSA/t PSA比值。结果　c PSA及c PSA/t PSA比值可有效地区分BPH和PCa(P <0 .0 0 5 ), 尤其是在诊断灰值区 (t PSA为 4～ 1 0ng/ml)时效果更显著。在以t PSA≤1 0 .0ng/ml和c PSA/t PSA≥0 .72为筛选界值联合对PCa进行筛选时, 临床概率敏感度为 93.8%。结论　c PSA的引入及c PSA/t PSA比值的应用, 对PCa的诊断具有重要临床意义, 尤其是在前列腺特异性抗原的诊断灰值区。

Abstract: Objective To evaluate the clinical value of serum complex prostate-specific antigen(c PSA) for the diagnosis of prostate cancer. Methods Serum samples were obtained from 72 men with untreated benign prostatic hyperplasia (BPH) and 38 men with untreated prostate cancer. The levels of c PSA, t PSA were determined by using auto immuno chemistry luminescence method. Results When all subjects were detected both total PSA and the complex PSA and complex/total PSA ratio were significantly different between p...