Metastasis?associated Lung Adenocarcinoma Transcript1(MALAT1) Expression in Middle Thoracic Esophageal Squamous Cell Cancer Tissues and Its Relationship with Prognosis
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摘要: 目的 探讨MALAT1的表达是否可以作为食管中段鳞癌患者根治术后的预后指标。方法 应用qRT-PCR法检测77例接受食管癌根治术治疗的食管中段鳞癌患者肿瘤组织及对应癌旁组织中MALAT1的表达水平及其与临床病理特征和预后的关系。结果 与癌旁组织相比，食管癌组织中MALAT1表达水平明显增高（P<0.001）。MALAT1的表达与患者T分期呈正相关。Kaplan-Meier生存分析显示MALAT1高表达组患者的术后无疾病进展时间（DFS）和总生存时间（OS）显著缩短（P=0.04, P=0.038）。多因素回归分析显示MALAT1表达水平对DFS和OS的风险比（HR）为1.73（95%CI=0.92~3.23, P=0.09）和1.71（95%CI=0.93~3.12, P=0.08）。结论 MALAT1的表达水平可能是接受根治术治疗的食管中段鳞癌患者的一项预后预测指标。Abstract: Objective To explore the potential role of metastasis?associated lung adenocarcinoma transcript1(MALAT1) expression in the prognosis of middle thoracic esophageal squamous cell cancer (ESCC) patients who received radical resection. Methods The expression of MALAT1 were evaluated in cancer tissues and paired adjacent normal tissues from 77 middle thoracic ESCC patients who received radical surgical resection using qRT-PCR. The correlation between the expression levels of MALAT1 and clinicopathological features and patients' survival were also analysed. Results MALAT1 expression was increased in ESCC tissues than that in adjacent normal tissues (P<0.001). MALAT1 level was positively related to pathological T (pT) stage (P=0.01). Kaplan-Meier analysis showed high expression levels ofMALAT1 were correlated with poor prognosis of ESCC patients. Patients with high MALAT1 expressionhad shorter DFS and OS than those with low MALAT1 expression (P=0.04 and 0.038). Multivariate analysisshowed that the HR of MALAT1 expression was 1.76 (95%CI=0.92-3.23, P=0.08) for DFS and 1.71 (95%CI=0.93-3.12, P=0.08) for OS. Conclusion MALAT1 expression may be a predictive marker for middle thoracic ESCC patients who received radical resection.
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