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Annexin A2在鼻咽癌组织中的表达及其临床意义

何火聪, 林少俊, 林可焴, 宗井凤, 陈超, 邹长棪, 潘剑茹, 苏颖

何火聪, 林少俊, 林可焴, 宗井凤, 陈超, 邹长棪, 潘剑茹, 苏颖. Annexin A2在鼻咽癌组织中的表达及其临床意义[J]. 肿瘤防治研究, 2015, 42(12): 1216-1220. DOI: 10.3971/j.issn.1000-8578.2015.12.010
引用本文: 何火聪, 林少俊, 林可焴, 宗井凤, 陈超, 邹长棪, 潘剑茹, 苏颖. Annexin A2在鼻咽癌组织中的表达及其临床意义[J]. 肿瘤防治研究, 2015, 42(12): 1216-1220. DOI: 10.3971/j.issn.1000-8578.2015.12.010
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HE Huocong, LIN Shaojun, LIN Keyu, ZONG Jingfeng, CHEN Chao, ZOU Changyan, PAN Jianru, SU Ying. Expression of Annexin A2 in Nasopharyngeal Carcinoma Tissues and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2015, 42(12): 1216-1220. DOI: 10.3971/j.issn.1000-8578.2015.12.010
Citation: HE Huocong, LIN Shaojun, LIN Keyu, ZONG Jingfeng, CHEN Chao, ZOU Changyan, PAN Jianru, SU Ying. Expression of Annexin A2 in Nasopharyngeal Carcinoma Tissues and Its Clinical Significance[J]. Cancer Research on Prevention and Treatment, 2015, 42(12): 1216-1220. DOI: 10.3971/j.issn.1000-8578.2015.12.010
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Annexin A2在鼻咽癌组织中的表达及其临床意义

  • 1. 350014 福州，国家临床重点专科建设项目福建省科技厅转化医学重点实验室 福建医科大学教学医院 福建省肿瘤医院放射生物学及肿瘤放射治疗学研究室；2. 350014 福州，福建省肿瘤医院放疗科；3. 350108 福州，福州大学生物科学与工程学院

基金项目: 国家自然科学基金（81472907）；福建省科技计划重点项目（2014Y0014）；福建省自然科学基金（2013J01117） ；福建省卫生厅创新课题（2011-CX-14）
详细信息
    作者简介:

    何火聪（1973-），男，硕士，主管技师，主要从事肿瘤放射生物学研究

    通讯作者:

    苏颖，E-mail: zjsuying@hotmail.com

  • 中图分类号: R735.2

Expression of Annexin A2 in Nasopharyngeal Carcinoma Tissues and Its Clinical Significance

  • 1. Laboratory of Radiation Oncology and Radiobiology, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Key Laboratory of Tumor Translational Medicine in Fujian Province, National Clinical Key Specialty Construction Program, Fuzhou 350014, China; 2. Department of Radiotherapy, Fujian Provincial Tumor Hospital, Fuzhou 350014, China; 3. College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China

摘要

    摘要
  • 摘要: 目的 探讨Annexin A2表达与鼻咽癌临床特征及预后的关系。方法 选取2012年2月至2012年7月初诊的131例经病理确诊的鼻咽癌肿瘤组织标本，免疫组织化学法检测Annexin A2表达情况。根据患者的性别、年龄、病理类型、肿瘤分期等临床资料，分析Annexin A2表达与临床分期、肿瘤局部复发和远处转移等关系。结果 Annexin A2在鼻咽癌中的阳性表达率为92.4%（121/131），表达强度差异在临床分期Ⅰ~Ⅳ期中均无统计学意义（P>0.05）。Annexin A2蛋白阴性表达者（-）比阳性表达者（+，++，+++）有较高的无局部复发生存率和无远处转移生存率，尽管差异无统计学意义（P>0.05），但两组之间曲线能较好的拉开。Cox模型分析结果显示：病理类型是鼻咽癌患者无局部复发生存时间的独立预后因素（P=0.039）。结论 Annexin A2蛋白高表达与鼻咽癌局部复发和远处转移是否具有相关性尚有待扩大样本量和延长随访时间进一步探讨。

     

    Abstract: Objective To investigate the relationship of Annexin A2 expression with the clinical characteristics and prognosis of nasopharyngeal carcinoma(NPC) patients. Methods We collected 131 cases of cancer tissues from the patients who were newly diagnosed as NPC. Annexin A2 expression was detected by immunohistochemistry method. Clinical data including gender, age, histological type, and tumor stage of patients were analyzed by SPSS18.0 software. The relationship between the expression of Annexin A2 protein, clinical stages, local recurrence and distant metastasis were investigated. Results The positive expression rate of Annexin A2 was 92.4% (121/131) in NPC tissues; however, there was no statistical significance in clinical Ⅰ-Ⅳ stage(P>0.05). Patients with negative expression (negative group) of Annexin A2 had a higher local recurrence-free survival rate and distant metastasis-free survival rate than those of positive expression (positive group) (P>0.05), but the curves between the two groups could be well opened. The pathological type was the independent factor of local recurrence-free survival after radiotherapy on NPC patients by univariate and multivariate analysis (P=0.039). Conclusion The further investigation, whether there is a relationship between the high expression of Annexin A2 protein and local recurrence, distant metastasis of NPC, will be carried out by increasing the number of patients and prolonging the follow-up time.

     

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出版历程
  • 收稿日期:  2015-08-24
  • 修回日期:  2015-10-20
  • 刊出日期:  2015-12-24

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