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肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展

李海涛, 谭超, 田书梅, 张晓磷, 赵云云

李海涛, 谭超, 田书梅, 张晓磷, 赵云云. 肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展[J]. 肿瘤防治研究, 2015, 42(11): 1165-1168. DOI: 10.3971/j.issn.1000-8578.2015.11.024
引用本文: 李海涛, 谭超, 田书梅, 张晓磷, 赵云云. 肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展[J]. 肿瘤防治研究, 2015, 42(11): 1165-1168. DOI: 10.3971/j.issn.1000-8578.2015.11.024
LI Haitao, TAN Chao, TIAN Shumei, ZHANG Xiaolin, ZHAO Yunyun. New Progress on Tumor-associated Macrophages in Tumor Microenvironment[J]. Cancer Research on Prevention and Treatment, 2015, 42(11): 1165-1168. DOI: 10.3971/j.issn.1000-8578.2015.11.024
Citation: LI Haitao, TAN Chao, TIAN Shumei, ZHANG Xiaolin, ZHAO Yunyun. New Progress on Tumor-associated Macrophages in Tumor Microenvironment[J]. Cancer Research on Prevention and Treatment, 2015, 42(11): 1165-1168. DOI: 10.3971/j.issn.1000-8578.2015.11.024

肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展

基金项目: 湖北省自然科学基金(2014CFB307);宜昌市自然科学基金(14301-13)
详细信息
    作者简介:

    李海涛(1979-),男,硕士,主治医师,主要从事影像生物介入治疗肿瘤等的研究

    通讯作者:

    谭超,E-mail: yczxyytanchao@sina.com

  • 中图分类号: R730.2

New Progress on Tumor-associated Macrophages in Tumor Microenvironment

  • 摘要: 众所周知,在肿瘤发生发展的各个阶段都有单核细胞通过血管壁进入肿瘤组织,这些单核细胞可分化形成具有独特表型的巨噬细胞,即肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)。TAMs是肿瘤微环境的重要组成部分,参与了肿瘤的发生、生长、侵袭及转移过程,其中,向肿瘤组织的转移是肿瘤恶性发展的关键步骤。本文将TAMs在肿瘤微环境形成中发挥作用的最新进展进行了总结,特别值得注意的是,细胞及动物实验研究表明,TAMs可为肿瘤的发生发展进程提供一个有利的微环境;同时,临床病理实验表明,TAMs在肿瘤内的累积与较差的临床疗效相关。最后,本文讨论了靶向TAMs的治疗手段作为一种间接癌症治疗新方法的可行性。

     

    Abstract: As we all know, monocytes can enter into the tumor tissues through the blood vessel wall at the various stages of tumor development. These monocytes can differentiate into macrophages, i.e. the tumor-associated macrophages(TAMs), with unique phenotypes. TAMs are important parts of the tumor microenviroment, involved in tumorigenesis, growth, invasion and metastasis, moreover, TAMs transferring into the tumor tissues is a critical step in the development of malignant tumors. In this review, the latest advances of TAMs on tumor microenvironment have been discussed noticeably, cell and animal studies proved that TAMs could make a favorable microenvironment to promote tumor development and progression. Meanwhile, clinicopathological studies suggest that the accumulation of TAMs in tumors is correlated with poor clinical outcome. At last, we also discuss the possibility of using TAM-targeting therapy as a promising novel strategy for cancer therapy.

     

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出版历程
  • 收稿日期:  2015-01-14
  • 修回日期:  2015-04-15
  • 刊出日期:  2015-11-24

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