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食管癌放疗患者淋巴细胞最低值与疗效和预后的关系

周冲, 练炼, 郭林, 康迪, 李向阳, 张伟, 卜祥兆, 殷海涛

周冲, 练炼, 郭林, 康迪, 李向阳, 张伟, 卜祥兆, 殷海涛. 食管癌放疗患者淋巴细胞最低值与疗效和预后的关系[J]. 肿瘤防治研究, 2015, 42(11): 1104-1108. DOI: 10.3971/j.issn.1000-8578.2015.11.010
引用本文: 周冲, 练炼, 郭林, 康迪, 李向阳, 张伟, 卜祥兆, 殷海涛. 食管癌放疗患者淋巴细胞最低值与疗效和预后的关系[J]. 肿瘤防治研究, 2015, 42(11): 1104-1108. DOI: 10.3971/j.issn.1000-8578.2015.11.010
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ZHOU Chong, LIAN Lian, GUO Lin, KANG Di, LI Xiangyang, Zhang Wei, BU Xiangzhao, YIN Haitao. Relationship Between Lymphocyte Nadir and Radiotherapy Efficacy or Prognosis of Patients with Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(11): 1104-1108. DOI: 10.3971/j.issn.1000-8578.2015.11.010
Citation: ZHOU Chong, LIAN Lian, GUO Lin, KANG Di, LI Xiangyang, Zhang Wei, BU Xiangzhao, YIN Haitao. Relationship Between Lymphocyte Nadir and Radiotherapy Efficacy or Prognosis of Patients with Esophageal Carcinoma[J]. Cancer Research on Prevention and Treatment, 2015, 42(11): 1104-1108. DOI: 10.3971/j.issn.1000-8578.2015.11.010
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食管癌放疗患者淋巴细胞最低值与疗效和预后的关系

  • 1. 221009 徐州，江苏东南大学附属徐州市中心医院肿瘤放疗科；2. 215131 苏州，苏州市相城区人民医院肿瘤内科

基金项目: 徐州市医学青年后备人才资助项目（2014005）
详细信息
    作者简介:

    周冲（1980-），男，硕士，主治医师，主要从事食管癌的放疗及综合治疗相关研究

    通讯作者:

    殷海涛，E-mail: baixia1108@126.com

  • 中图分类号: R735.1

Relationship Between Lymphocyte Nadir and Radiotherapy Efficacy or Prognosis of Patients with Esophageal Carcinoma

  • 1. Department of Radiation Oncology, Xuzhou Central Hospital, The Affiliated Hospital of Southeast University, Xuzhou 221009, China, 2. Department of Oncology, Suzhou Xiangcheng People's Hospital, Suzhou 215131, China

摘要

    摘要
  • 摘要: 目的 评价食管癌在放疗期间淋巴细胞抑制与近期疗效及预后的关系。方法 回顾性分析2011年1月至2012年12月在徐州中心医院接受根治性放疗的112例食管癌患者，记录从放疗开始至放疗结束1年期间内淋巴细胞计数。卡方检验分析临床病理资料及近期疗效与放疗期间淋巴细胞最低值的关系。采用单因素及多因素Cox回归模型分析淋巴细胞最低值与预后的关系。结果 全组患者放疗前淋巴细胞计数为（1.78±0.76）个/毫米3，放疗过程中淋巴细胞计数最低值为（0.45±0.22）个/毫米3，放疗结束1年淋巴细胞计数为（1.15±0.39）个/毫米3。食管癌病变长度、病变最大宽度及是否行同期化疗是影响放疗间淋巴细胞降低的因素（P<0.05）。放疗期间淋巴细胞最低值≥0.5个/毫米3组与＜0.5个/毫米3组近期有效率分别为92%与70%（χ2=7.66, P=0.007）。生存分析显示淋巴细胞最低值＜0.5个/毫米3组生存低于≥0.5个/毫米3组（χ2=4.489, P=0.034），两组1年及2年生存率分别为51.6%、37.4%及81.3%、54.0%。单因素及多因素Cox回归分析均显示，TNM分期、病变长度及淋巴细胞最低值是影响生存的独立因素。

     

    Abstract: Objective To evaluate the predictive value of radiation-induced lymphopenia in short-term effect and prognosis of patients with esophageal carcinoma who received radiotherapy(RT). Methods We retrospectively analyzed clinicopathologic data of 112 patients undergoing radical intent RT in Xuzhou Gentral Hospital from Jan.2011 to Dec. 2012. Total lymphocyte counts were collected from the beginning to the end of RT for one year. The relationship between lymphocyte nadirs and clinicopathologic data, shortterm effect were assessed with Chi-squared test. Univariate and multivariate Cox analysis were used to assess the association between lymphocyte nadir and overall survival (OS). Results The total lymphocyte count for all patients before RT was (1.78±0.76) cells/mm3. The lymphocyte nadir during RT and the total lymphocyte count at one year after RT were (0.45±0.22) and (1.15±0.39) cells/mm3, respectively. Tumor length, maximum tumor width, and receipt of concurrent chemotherapy were influential factors for radiationinduced lymphopenia (all P<0.05). The response rate for patients with high and low lymphocyte nadir (≥and <0.5 cells/mm3) were 92% and 70%, respectively (χ2=7.66, P=0.007). The 1- and 2-year survival rates of patients with low lymphocyte nadir were significantly worse than that of high lymphocyte nadir groups (51.6%, 37.4% vs. 81.3%, 54.0%, χ2= 4.489, P=0.034). Both univariate and multivariate analysis revealed that TNM stage, tumor length and lymphocyte nadirs were independent factors for OS. Conclusion Lymphocyte nadir during RT, as an inexpensive and convenient marker, could predict short-term effect and provide prognostic values for esophageal carcinoma patients who received radical RT.

     

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    • 参考文献(15)
  • [1] Campian JL, Ye X, Brock M, et al. Treatment-related lymphopenia in patients with stage Ⅲ non-small-cell lung cancer[J]. Cancer Invest, 2013, 31(3): 183-8.
    [2] Tang C, Liao Z, Gomez D, et al. Lymphopenia association with gross tumor volume and lung V5 and its effects on non-small cell lung cancer patient outcomes[J]. Int J Radiat Oncol Biol Phys, 20 14, 89(5): 1084-91.
    [3] Balmanoukian A, Ye X, Herman J, et al. The association between treatment-related lymphopenia and survival in newly diagnosed patients with resected adenocarcinoma of the pancreas[J]. Cancer Invest, 2012, 30(8): 571-6.
    [4] Yovino S, Kleinberg L, Grossman SA, et al. The etiology of treatment-related lymphopenia in patients with malignant gliomas: modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells[J]. Cancer Invest, 2013, 31 (2): 140-4.
    [5] Campian JL, Sarai G, Ye X, et al. Association between severe treatment-related lymphopenia and progression-free survival in patients with newly diagnosed squamous cell head and neck cancer[J]. Head Neck, 2014, 36(12): 1747-53.
    [6] Wang QF, Xiao ZF, Wang LH, et al. Efficacy of three-dimensional conformal radiotherapy for 132 patients with esophageal carcinoma[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2009, 18 (1): 47-51. [王奇峰, 肖泽芬, 王绿化, 等. 132例食管癌三维 适形放疗的疗效分析[J]. 中华放射肿瘤学杂志, 2009, 18(1): 47 -51.]
    [7] Han C, Ren XJ, Wang L, et al. Evaluating short-term radiotherapeutic effect on esophageal cancer by barium meal combined with CT scans[J]. Zhonghua Fang She Zhong Liu Xue Za Zhi, 2013, 22(1): 26-9. [韩春, 任雪娇, 王澜, 等. 钡餐造影结 合CT评价食管癌放疗近期疗效的研究[J]. 中华放射肿瘤学杂 志, 2013, 22(1): 26-9.]
    [8] Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift[J]. J Natl Cancer Inst, 2013, 10 5(4): 256-65.
    [9] Gameiro SR, Jammeh ML, Wattenberg MM, et al. Radiationinduced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing[J]. Oncotarget, 2014, 5(2): 403-16.
    [10] Park B, Yee C, Lee KM. The effect of radiation on the immune response to cancers[J]. Int J Mol Sci, 2014, 15(1): 927-43.
    [11] Nakamura N, Kusunoki Y, Akiyama M. Radiosensitivity of CD4 or CD8 positive human T-lymphocytes by an in vitro colony formation assay[J]. Radiat Res, 1990, 123(2): 224-7.
    [12] Ellsworth S, Balmanoukian A, Kos F, et al. Sustained CD4+T celldriven lymphopenia without a compensatory IL-7/IL-15 response among high-grade glioma patients treated with radiation and temozolomide[J]. Oncoimmunology, 2014, 3(1): e27357.
    [13] Kuo P, Bratman SV, Shultz DB, et al. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response[J]. Clin Cancer Res, 2014, 20(21): 5558-69.
    [14] Verastegui EL, Morales RB, Barrera-Franco JL, et al. Long-term immune dysfunction after radiotherapy to the head and neck area[J]. Int Immunopharmacol, 2003, 3(8): 1093-104.
    [15] Grossman SA, Ye X, Lesser G, et al. Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide[J]. Clin Cancer Res, 2011, 17(16): 5473-80.
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出版历程
  • 收稿日期:  2015-01-19
  • 修回日期:  2015-04-27
  • 刊出日期:  2015-11-24

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